Nonsense‐mediated decay targets have multiple sequence‐related features that can inhibit translation

Nonsense‐mediated decay targets have multiple sequence‐related features that can inhibit translation

Nonsense‐mediated mRNA decay (NMD) is a surveillance system that eliminates transcripts with premature termination codons. In this study, we show that mRNAs targeted by NMD are also suppressed at the translational level. The low translational efficiency (TE) is a consequence of multiple features act...

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Bibliographic Details
Main Authors: Zhenguo Zhang, Li Zhou, Landian Hu, Yufei Zhu, Heng Xu, Yang Liu, Xianfen Chen, Xianfu Yi, Xiangyin Kong, Laurence D Hurst
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
nonsense‐mediated mRNA decay
translation efficiency
translation repression
Online Access:https://doi.org/10.1038/msb.2010.101

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