Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration
Neuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue. Upon viral infection of the CNS, microglia become activated and start to produce inflammatory mediators important for clearance of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/7/809 |
| _version_ | 1797433189311971328 |
|---|---|
| author | Magdalena Patrycy Marcin Chodkowski Malgorzata Krzyzowska |
| author_facet | Magdalena Patrycy Marcin Chodkowski Malgorzata Krzyzowska |
| author_sort | Magdalena Patrycy |
| collection | DOAJ |
| description | Neuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue. Upon viral infection of the CNS, microglia become activated and start to produce inflammatory mediators important for clearance of the virus, but an excessive neuroinflammation can harm nearby neuronal cells. Herpesviruses express several molecular mechanisms, which can modulate apoptosis of infected neurons, astrocytes and microglia but also divert immune response initiated by the infected cells. In this review we also describe the link between virus-related neuroinflammation, and development of neurodegenerative diseases. |
| first_indexed | 2024-03-09T10:13:29Z |
| format | Article |
| id | doaj.art-78e0070eacc54da58d6acc74d064593b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T10:13:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-78e0070eacc54da58d6acc74d064593b2023-12-01T22:32:57ZengMDPI AGPathogens2076-08172022-07-0111780910.3390/pathogens11070809Role of Microglia in Herpesvirus-Related Neuroinflammation and NeurodegenerationMagdalena Patrycy0Marcin Chodkowski1Malgorzata Krzyzowska2Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandMilitary Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandMilitary Institute of Hygiene and Epidemiology, 01-163 Warsaw, PolandNeuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue. Upon viral infection of the CNS, microglia become activated and start to produce inflammatory mediators important for clearance of the virus, but an excessive neuroinflammation can harm nearby neuronal cells. Herpesviruses express several molecular mechanisms, which can modulate apoptosis of infected neurons, astrocytes and microglia but also divert immune response initiated by the infected cells. In this review we also describe the link between virus-related neuroinflammation, and development of neurodegenerative diseases.https://www.mdpi.com/2076-0817/11/7/809neuroinflammationHSVHerpesviridaemicrogliaapoptosisneurodegeneration |
| spellingShingle | Magdalena Patrycy Marcin Chodkowski Malgorzata Krzyzowska Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration Pathogens neuroinflammation HSV Herpesviridae microglia apoptosis neurodegeneration |
| title | Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration |
| title_full | Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration |
| title_fullStr | Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration |
| title_full_unstemmed | Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration |
| title_short | Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration |
| title_sort | role of microglia in herpesvirus related neuroinflammation and neurodegeneration |
| topic | neuroinflammation HSV Herpesviridae microglia apoptosis neurodegeneration |
| url | https://www.mdpi.com/2076-0817/11/7/809 |
| work_keys_str_mv | AT magdalenapatrycy roleofmicrogliainherpesvirusrelatedneuroinflammationandneurodegeneration AT marcinchodkowski roleofmicrogliainherpesvirusrelatedneuroinflammationandneurodegeneration AT malgorzatakrzyzowska roleofmicrogliainherpesvirusrelatedneuroinflammationandneurodegeneration |