Screening for Active Compounds Targeting Human Natural Killer Cell Activation Identifying Daphnetin as an Enhancer for IFN-γ Production and Direct Cytotoxicity

Screening for Active Compounds Targeting Human Natural Killer Cell Activation Identifying Daphnetin as an Enhancer for IFN-γ Production and Direct Cytotoxicity

Natural killer (NK) cells are a potent weapon against tumor and viral infection. Finding active compounds with the capacity of enhancing NK cell effector functions will be effective to develop new anti-cancer drugs. In this study, we initially screened 287 commercially available active compounds by...

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Bibliographic Details
Main Authors:	Baige Yao, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Lili Wang, Shuju Zhang, Minghui Huang, Erqiang Wang, Peiwen Xiong, Ting Luo, Liping Li, Sujie Jia, Yafei Deng, Youcai Deng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Series:	Frontiers in Immunology
Subjects:	natural killer cell Daphnetin interferon (IFN)-γ PI3K-Akt mTOR
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.680611/full

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