Lactate overload inhibits myogenic activity in C2C12 myotubes

Lactate overload inhibits myogenic activity in C2C12 myotubes

Lactate (LA), an endogenous metabolite produced from pyruvate, can accumulate in skeletal muscle in certain conditions including major diseases, as well as during intensive exercise. Using differentiated C2C12 myotubes, we evaluated the early (1-h) and delayed (24-h) effects of LA (8 mM) on mechanis...

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Bibliographic Details
Main Authors: Oh Sarah Se-Jung, Kim Sujin, Moon Sohee, Park Dong-Ho, Kang Ju-Hee
Format: Article
Language:English
Published: De Gruyter 2019-03-01
Series:Open Life Sciences
Subjects:
lactate
skeletal muscle
myogenesis
akt
ampk
Online Access:https://doi.org/10.1515/biol-2019-0004

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