Rosiglitazone Mitigates Dexamethasone-Induced Depression in Mice via Modulating Brain Glucose Metabolism and AMPK/mTOR Signaling Pathway

Rosiglitazone Mitigates Dexamethasone-Induced Depression in Mice via Modulating Brain Glucose Metabolism and AMPK/mTOR Signaling Pathway

Major depressive disorder (MDD) is a common, complex disease with poorly understood pathogenesis. Disruption of glucose metabolism is implicated in the pathogenesis of depression. AMP-activated protein kinase (AMPK) has been shown to regulate the activity of several kinases, including pAKT, p38MAPK,...

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Bibliographic Details
Main Authors: Aisha Alhaddad, Asmaa Radwan, Noha A. Mohamed, Eman T. Mehanna, Yasser M. Mostafa, Norhan M. El-Sayed, Shaimaa A. Fattah
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
rosiglitazone
major depressive disorder
dexamethasone
glucose metabolism
AMP-activated protein kinase
mitogen-activated protein kinases
Online Access:https://www.mdpi.com/2227-9059/11/3/860

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