The protective effect of taurine against liver disorder induced by gentamicin in male rats
The present study was carried out to investigate the effects of an amino acid taurine on gentamicin-induced liver disorder in male rats. Twenty four male rats were used in this study, the animals divided into four groups, each group contained six rats including: G1 normal group, G2 injection IP with...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-05-01
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| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://mail.jsci.utq.edu.iq/index.php/main/article/view/242 |
| _version_ | 1797454218697637888 |
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| author | Orass Saad Kahyoon Salam H. Flayyih Khalid G, Al-Fartosi |
| author_facet | Orass Saad Kahyoon Salam H. Flayyih Khalid G, Al-Fartosi |
| author_sort | Orass Saad Kahyoon |
| collection | DOAJ |
| description | The present study was carried out to investigate the effects of an amino acid taurine on gentamicin-induced liver disorder in male rats. Twenty four male rats were used in this study, the animals divided into four groups, each group contained six rats including: G1 normal group, G2 injection IP with 100mg/kg of gentamicin only for 10 days, G3 injection IP with 100mg/kg of taurine only for 10 days, G4 injection IP with 100mg/kg of gentamicin and injection IP with 100mg/kg of taurine for 10 days, The result shows significant increase (p<0.05) in liver enzymes ALT, AST, ALP and significant increase in TC, TG, LDL with marked decrease in HDL levels in gentamicin group compared with normal group. This animal study suggests that the treatment with gentamicin plus taurine protects against gentamicin-induced acute liver injury by a significant (p<0.05) and improvement in the biochemical markers of liver and normalized lipid profiles. |
| first_indexed | 2024-03-09T15:34:05Z |
| format | Article |
| id | doaj.art-78e9b23aa1f54cb1946ae5fbae2f7af5 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-09T15:34:05Z |
| publishDate | 2019-05-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-78e9b23aa1f54cb1946ae5fbae2f7af52023-11-26T09:40:58ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-05-0171The protective effect of taurine against liver disorder induced by gentamicin in male ratsOrass Saad Kahyoon0Salam H. Flayyih1Khalid G, Al-Fartosi2Department of Physiology/College of Veterinary medicine/University of Thi-Qar. IraqDepartment of Basic Sciences/College of Nursing/University of Thi-Qar, IraqDeparetment of Biology/College of Sciences/University of Thi-Qar, IraqThe present study was carried out to investigate the effects of an amino acid taurine on gentamicin-induced liver disorder in male rats. Twenty four male rats were used in this study, the animals divided into four groups, each group contained six rats including: G1 normal group, G2 injection IP with 100mg/kg of gentamicin only for 10 days, G3 injection IP with 100mg/kg of taurine only for 10 days, G4 injection IP with 100mg/kg of gentamicin and injection IP with 100mg/kg of taurine for 10 days, The result shows significant increase (p<0.05) in liver enzymes ALT, AST, ALP and significant increase in TC, TG, LDL with marked decrease in HDL levels in gentamicin group compared with normal group. This animal study suggests that the treatment with gentamicin plus taurine protects against gentamicin-induced acute liver injury by a significant (p<0.05) and improvement in the biochemical markers of liver and normalized lipid profiles.https://mail.jsci.utq.edu.iq/index.php/main/article/view/242GentamicinTaurineLiverRats. ALTASTALP |
| spellingShingle | Orass Saad Kahyoon Salam H. Flayyih Khalid G, Al-Fartosi The protective effect of taurine against liver disorder induced by gentamicin in male rats مجلة علوم ذي قار Gentamicin Taurine Liver Rats. ALT AST ALP |
| title | The protective effect of taurine against liver disorder induced by gentamicin in male rats |
| title_full | The protective effect of taurine against liver disorder induced by gentamicin in male rats |
| title_fullStr | The protective effect of taurine against liver disorder induced by gentamicin in male rats |
| title_full_unstemmed | The protective effect of taurine against liver disorder induced by gentamicin in male rats |
| title_short | The protective effect of taurine against liver disorder induced by gentamicin in male rats |
| title_sort | protective effect of taurine against liver disorder induced by gentamicin in male rats |
| topic | Gentamicin Taurine Liver Rats. ALT AST ALP |
| url | https://mail.jsci.utq.edu.iq/index.php/main/article/view/242 |
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