The effects of acitretin on ovarian reserve: An experimental study in rats
Background and Design: Acitretin is widely used on many dermatological diseases. No adequate studies have evaluated its effects on ovarian reserve. Thus, this experimental study aimed to investigate the possible effects of acitretin on ovarian reserve by examining ovarian follicle counts and serum a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-03-01
|
| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
| Subjects: | |
| Online Access: | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-37650&look4= |
| _version_ | 1828014889836216320 |
|---|---|
| author | Münevver Güven Tolga Atakul Serkan Yaşar Çelik Mustafa Yılmaz Buket Demirci |
| author_facet | Münevver Güven Tolga Atakul Serkan Yaşar Çelik Mustafa Yılmaz Buket Demirci |
| author_sort | Münevver Güven |
| collection | DOAJ |
| description | Background and Design: Acitretin is widely used on many dermatological diseases. No adequate studies have evaluated its effects on ovarian reserve. Thus, this experimental study aimed to investigate the possible effects of acitretin on ovarian reserve by examining ovarian follicle counts and serum anti-Mullerian hormone (AMH) values.
Materials and Methods: This study randomly distributed 31 female Wistar albino rats into 3 groups including one control group (group 1) and two equal experimental groups. Acitretin was given at doses of 0 mg/kg/day (group 1, n=11), 1 mg/kg/day (group 2, n=10), and 5 mg/ kg/day (group 3, n=10) for 4 weeks. All the rats in three groups were kept drug-free for 4 weeks before being sacrificed. The blood samples and both ovarian tissues were obtained from the rats. Serum values of AMH were assessed and the number of ovarian follicles was counted by histopathological examination.
Results: The AMH levels were lower in both acitretin groups (groups 2 and 3) than group 1. However, no significant difference was found between the groups in terms of AMH values (p=0.338). Primordial, secondary, tertiary, and total follicle numbers in group 3 were statistically lower than that of groups 1 and 2. The number of primary follicles in group 1 was statistically higher than that of groups 2 and 3. Additionally, the number of secondary follicles in group 2 was statistically higher than that of group 1.
Conclusion: This study showed that ovarian reserve can be affected by acitretin treatment. Particularly, high doses of acitretin may reduce ovarian reserve. Further experimental and clinical studies are needed to clarify the effect of acitretin on ovarian reserve. |
| first_indexed | 2024-04-10T10:09:04Z |
| format | Article |
| id | doaj.art-78ec1ccbb2ec4cd2b79c6ec31d974e14 |
| institution | Directory Open Access Journal |
| issn | 2651-5164 |
| language | English |
| last_indexed | 2024-04-10T10:09:04Z |
| publishDate | 2022-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj.art-78ec1ccbb2ec4cd2b79c6ec31d974e142023-02-15T16:22:20ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642022-03-01561242710.4274/turkderm.galenos.2021.37650The effects of acitretin on ovarian reserve: An experimental study in ratsMünevver Güven0https://orcid.org/0000-0001-8643-435XTolga Atakul1https://orcid.org/0000-0002-0219-000XSerkan Yaşar Çelik2https://orcid.org/0000-0001-6557-1451Mustafa Yılmaz3https://orcid.org/0000-0002-3353-6595Buket Demirci4https://orcid.org/0000-0002-3442-5061Aydın Adnan Menderes University Faculty of Medicine, Department of Dermatology, Aydın, TurkeyAydın Adnan Menderes University Faculty of Medicine, Department of Obstetrics and Gynecology, Aydın, TurkeyMuğla Sıtkı Koçman University Faculty of Medicine, Department of Pathology, Muğla, TurkeyAydın Adnan Menderes University Faculty of Medicine, Department of Biochemistry, Aydın, TurkeyAydın Adnan Menderes University Faculty of Medicine, Department of Medical Pharmacology, Aydın, TurkeyBackground and Design: Acitretin is widely used on many dermatological diseases. No adequate studies have evaluated its effects on ovarian reserve. Thus, this experimental study aimed to investigate the possible effects of acitretin on ovarian reserve by examining ovarian follicle counts and serum anti-Mullerian hormone (AMH) values. Materials and Methods: This study randomly distributed 31 female Wistar albino rats into 3 groups including one control group (group 1) and two equal experimental groups. Acitretin was given at doses of 0 mg/kg/day (group 1, n=11), 1 mg/kg/day (group 2, n=10), and 5 mg/ kg/day (group 3, n=10) for 4 weeks. All the rats in three groups were kept drug-free for 4 weeks before being sacrificed. The blood samples and both ovarian tissues were obtained from the rats. Serum values of AMH were assessed and the number of ovarian follicles was counted by histopathological examination. Results: The AMH levels were lower in both acitretin groups (groups 2 and 3) than group 1. However, no significant difference was found between the groups in terms of AMH values (p=0.338). Primordial, secondary, tertiary, and total follicle numbers in group 3 were statistically lower than that of groups 1 and 2. The number of primary follicles in group 1 was statistically higher than that of groups 2 and 3. Additionally, the number of secondary follicles in group 2 was statistically higher than that of group 1. Conclusion: This study showed that ovarian reserve can be affected by acitretin treatment. Particularly, high doses of acitretin may reduce ovarian reserve. Further experimental and clinical studies are needed to clarify the effect of acitretin on ovarian reserve.https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-37650&look4=acitretinanti-mullerian hormoneovarian reserve |
| spellingShingle | Münevver Güven Tolga Atakul Serkan Yaşar Çelik Mustafa Yılmaz Buket Demirci The effects of acitretin on ovarian reserve: An experimental study in rats Turkderm Turkish Archives of Dermatology and Venereology acitretin anti-mullerian hormone ovarian reserve |
| title | The effects of acitretin on ovarian reserve: An experimental study in rats |
| title_full | The effects of acitretin on ovarian reserve: An experimental study in rats |
| title_fullStr | The effects of acitretin on ovarian reserve: An experimental study in rats |
| title_full_unstemmed | The effects of acitretin on ovarian reserve: An experimental study in rats |
| title_short | The effects of acitretin on ovarian reserve: An experimental study in rats |
| title_sort | effects of acitretin on ovarian reserve an experimental study in rats |
| topic | acitretin anti-mullerian hormone ovarian reserve |
| url | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-37650&look4= |
| work_keys_str_mv | AT munevverguven theeffectsofacitretinonovarianreserveanexperimentalstudyinrats AT tolgaatakul theeffectsofacitretinonovarianreserveanexperimentalstudyinrats AT serkanyasarcelik theeffectsofacitretinonovarianreserveanexperimentalstudyinrats AT mustafayılmaz theeffectsofacitretinonovarianreserveanexperimentalstudyinrats AT buketdemirci theeffectsofacitretinonovarianreserveanexperimentalstudyinrats AT munevverguven effectsofacitretinonovarianreserveanexperimentalstudyinrats AT tolgaatakul effectsofacitretinonovarianreserveanexperimentalstudyinrats AT serkanyasarcelik effectsofacitretinonovarianreserveanexperimentalstudyinrats AT mustafayılmaz effectsofacitretinonovarianreserveanexperimentalstudyinrats AT buketdemirci effectsofacitretinonovarianreserveanexperimentalstudyinrats |