Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points
Summary: Neutrophils are the largest population of leucocytes and are among the first cells of the innate immune system to fight against intruding pathogens. In patients with cirrhosis, neutrophils exhibit altered functionality, including changes in phagocytic ability, bacterial killing, chemotaxis,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | JHEP Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555923002021 |
| _version_ | 1797647826050613248 |
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| author | Irina Balazs Vanessa Stadlbauer |
| author_facet | Irina Balazs Vanessa Stadlbauer |
| author_sort | Irina Balazs |
| collection | DOAJ |
| description | Summary: Neutrophils are the largest population of leucocytes and are among the first cells of the innate immune system to fight against intruding pathogens. In patients with cirrhosis, neutrophils exhibit altered functionality, including changes in phagocytic ability, bacterial killing, chemotaxis, degranulation, reactive oxygen species production and NET (neutrophil extracellular trap) formation. This results in their inability to mount an adequate antibacterial response and protect the individual from infection. Prognosis and survival in patients with cirrhosis are greatly influenced by the development of infectious complications. Multidrug-resistant bacterial infections in patients with cirrhosis are currently a growing problem worldwide; therefore, alternative methods for the prevention and treatment of bacterial infections in cirrhosis are urgently needed. The prevention and treatment of neutrophil dysfunction could be a potential way to protect patients from bacterial infections. However, the reasons for changes in neutrophil function in cirrhosis are still not completely understood, which limits the development of efficient therapeutic strategies. Both cellular and serum factors have been proposed to contribute to the functional impairment of neutrophils. Herein, we review the current knowledge on features and proposed causes of neutrophil dysfunction in cirrhosis, with a focus on current knowledge gaps and limitations, as well as opportunities for future investigations in this field. |
| first_indexed | 2024-03-11T15:22:08Z |
| format | Article |
| id | doaj.art-78ec796cf64147bbb4d8a1cc71b676f2 |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-03-11T15:22:08Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-78ec796cf64147bbb4d8a1cc71b676f22023-10-28T05:09:32ZengElsevierJHEP Reports2589-55592023-11-01511100871Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey pointsIrina Balazs0Vanessa Stadlbauer1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria; Center for Biomarker Research in Medicine (CBmed), Graz, AustriaDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria; Center for Biomarker Research in Medicine (CBmed), Graz, Austria; Corresponding author. Address: Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria; Tel.: +43/316/385 82282.Summary: Neutrophils are the largest population of leucocytes and are among the first cells of the innate immune system to fight against intruding pathogens. In patients with cirrhosis, neutrophils exhibit altered functionality, including changes in phagocytic ability, bacterial killing, chemotaxis, degranulation, reactive oxygen species production and NET (neutrophil extracellular trap) formation. This results in their inability to mount an adequate antibacterial response and protect the individual from infection. Prognosis and survival in patients with cirrhosis are greatly influenced by the development of infectious complications. Multidrug-resistant bacterial infections in patients with cirrhosis are currently a growing problem worldwide; therefore, alternative methods for the prevention and treatment of bacterial infections in cirrhosis are urgently needed. The prevention and treatment of neutrophil dysfunction could be a potential way to protect patients from bacterial infections. However, the reasons for changes in neutrophil function in cirrhosis are still not completely understood, which limits the development of efficient therapeutic strategies. Both cellular and serum factors have been proposed to contribute to the functional impairment of neutrophils. Herein, we review the current knowledge on features and proposed causes of neutrophil dysfunction in cirrhosis, with a focus on current knowledge gaps and limitations, as well as opportunities for future investigations in this field.http://www.sciencedirect.com/science/article/pii/S2589555923002021neutrophilscirrhosisphagocytosisROSchemotaxisNETs |
| spellingShingle | Irina Balazs Vanessa Stadlbauer Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points JHEP Reports neutrophils cirrhosis phagocytosis ROS chemotaxis NETs |
| title | Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points |
| title_full | Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points |
| title_fullStr | Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points |
| title_full_unstemmed | Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points |
| title_short | Circulating neutrophil anti-pathogen dysfunction in cirrhosisKey points |
| title_sort | circulating neutrophil anti pathogen dysfunction in cirrhosiskey points |
| topic | neutrophils cirrhosis phagocytosis ROS chemotaxis NETs |
| url | http://www.sciencedirect.com/science/article/pii/S2589555923002021 |
| work_keys_str_mv | AT irinabalazs circulatingneutrophilantipathogendysfunctionincirrhosiskeypoints AT vanessastadlbauer circulatingneutrophilantipathogendysfunctionincirrhosiskeypoints |