Bioinformatics Modelling and Metabolic Engineering of the Branched Chain Amino Acid Pathway for Specific Production of Mycosubtilin Isoforms in <i>Bacillus subtilis</i>

Bioinformatics Modelling and Metabolic Engineering of the Branched Chain Amino Acid Pathway for Specific Production of Mycosubtilin Isoforms in <i>Bacillus subtilis</i>

Mycosubtilin belongs to the family of lipopeptides. Different isoforms with various antifungal activities can be obtained according to the length and the isomery of the fatty acid. In this work, the activities of the mycosubtilin isoforms were first studied against the pathogen <i>Aspergillus...

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Bibliographic Details
Main Authors: Jean-Sébastien Guez, Françoise Coucheney, Joany Guy, Max Béchet, Pierre Fontanille, Nour-Eddine Chihib, Joachim Niehren, François Coutte, Philippe Jacques
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Metabolites
Subjects:
metabolic engineering
bioinformatic modelling
lipopeptides
mycosubtilin
antifungal
fatty acids
Online Access:https://www.mdpi.com/2218-1989/12/2/107

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