Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: A proof of principle

Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: A proof of principle

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, which remains difficult to cure. The very high recurrence rate has been partly attributed to the presence of GBM stem-like cells (GSCs) within the tumors, which have been associated with elevated chemokine receptor 4 (CXCR4) ex...

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Bibliographic Details
Main Authors: Judit Sanchez Gil, Maxime Dubois, Virginie Neirinckx, Arnaud Lombard, Natacha Coppieters, Paolo D’Arrigo, Damla Isci, Therese Aldenhoff, Benoit Brouwers, Cédric Lassence, Bernard Rogister, Marielle Lebrun, Catherine Sadzot-Delvaux
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
virotherapy
HSV
glioblastoma
glioblastoma stem-like cells
GBM
GSC
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052200078X

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