Development and Validation of a High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC-MS/MS) Method for Quantification of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) in Human Plasma

Development and Validation of a High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC-MS/MS) Method for Quantification of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) in Human Plasma

Molnupiravir is an antiviral drug against viral RNA polymerase activity approved by the FDA for the treatment of COVID-19, which is metabolized to β-D-N4-hydroxycytidine (NHC) in human blood plasma. A novel method was developed and validated for quantifying NHC in human plasma within the analytical...

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Bibliographic Details
Main Authors: Timofey Komarov, Polina Karnakova, Olga Archakova, Dana Shchelgacheva, Natalia Bagaeva, Mariia Popova, Polina Karpova, Kira Zaslavskaya, Petr Bely, Igor Shohin
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomedicines
Subjects:
β-D-N4-hydroxycytidine
NHC
molnupiravir
COVID-19
plasma
HPLC-MS/MS
Online Access:https://www.mdpi.com/2227-9059/11/9/2356

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