A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder
Alcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the United States. It contributes to over 140,000 annual deaths, to over 200 related diseases and health conditions globally, and accounts for 5.1% of the global disease burden. Despite its substantial impact, AUD...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/3/294 |
| _version_ | 1827306834456739840 |
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| author | Muhammet Celik Mark S. Gold Brian Fuehrlein |
| author_facet | Muhammet Celik Mark S. Gold Brian Fuehrlein |
| author_sort | Muhammet Celik |
| collection | DOAJ |
| description | Alcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the United States. It contributes to over 140,000 annual deaths, to over 200 related diseases and health conditions globally, and accounts for 5.1% of the global disease burden. Despite its substantial impact, AUD remains undertreated, marked by a scarcity of approved medications. This paper explores the current treatment landscape and novel strategies for both alcohol withdrawal syndrome and AUD. Promising results, including the use of psychedelics alongside psychotherapy, noninvasive neural-circuit-based interventions, phosphodiesterase-4 inhibitors, and GLP-1 receptor agonists, have emerged from recent studies. While these advancements show potential, further research is crucial for a comprehensive understanding of their effectiveness. The clear shortage of approved medications and other treatment modalities underscores the pressing need for ongoing research. |
| first_indexed | 2024-04-24T18:29:08Z |
| format | Article |
| id | doaj.art-78ef37c9d9fb4c32b06304b5498c10a4 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-24T18:29:08Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-78ef37c9d9fb4c32b06304b5498c10a42024-03-27T13:28:53ZengMDPI AGBrain Sciences2076-34252024-03-0114329410.3390/brainsci14030294A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use DisorderMuhammet Celik0Mark S. Gold1Brian Fuehrlein2New York Medical College at Saint Joseph’s Medical Center, Yonkers, NY 10705, USADepartment of Psychiatry, School of Medicine, Washington University, St. Louis, MO 63130, USAMental Health Service Line, VA Connecticut Healthcare System, West Haven, CT 06516, USAAlcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the United States. It contributes to over 140,000 annual deaths, to over 200 related diseases and health conditions globally, and accounts for 5.1% of the global disease burden. Despite its substantial impact, AUD remains undertreated, marked by a scarcity of approved medications. This paper explores the current treatment landscape and novel strategies for both alcohol withdrawal syndrome and AUD. Promising results, including the use of psychedelics alongside psychotherapy, noninvasive neural-circuit-based interventions, phosphodiesterase-4 inhibitors, and GLP-1 receptor agonists, have emerged from recent studies. While these advancements show potential, further research is crucial for a comprehensive understanding of their effectiveness. The clear shortage of approved medications and other treatment modalities underscores the pressing need for ongoing research.https://www.mdpi.com/2076-3425/14/3/294alcoholalcohol use disorder (AUD)withdrawal |
| spellingShingle | Muhammet Celik Mark S. Gold Brian Fuehrlein A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder Brain Sciences alcohol alcohol use disorder (AUD) withdrawal |
| title | A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder |
| title_full | A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder |
| title_fullStr | A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder |
| title_full_unstemmed | A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder |
| title_short | A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder |
| title_sort | narrative review of current and emerging trends in the treatment of alcohol use disorder |
| topic | alcohol alcohol use disorder (AUD) withdrawal |
| url | https://www.mdpi.com/2076-3425/14/3/294 |
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