10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus
The aim of the study was to assess the 10-year risk of fractures (FRAX®), taking into account the values of bone mineral density (BMD) and trabecular bone index (TBI) in a population sample of women over 55 years of age with type 2 diabetes mellitus (DM2).Materials and methods. The study was carried...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2019-08-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/3117 |
| _version_ | 1827962497681850368 |
|---|---|
| author | E. S. Mazurenko O. D. Rymar L. V. Scherbakova Y. V. Khrapova M. P. Isayeva I. V. Munts J. Hubacek M. Bobak S. K. Malutina |
| author_facet | E. S. Mazurenko O. D. Rymar L. V. Scherbakova Y. V. Khrapova M. P. Isayeva I. V. Munts J. Hubacek M. Bobak S. K. Malutina |
| author_sort | E. S. Mazurenko |
| collection | DOAJ |
| description | The aim of the study was to assess the 10-year risk of fractures (FRAX®), taking into account the values of bone mineral density (BMD) and trabecular bone index (TBI) in a population sample of women over 55 years of age with type 2 diabetes mellitus (DM2).Materials and methods. The study was carried out on the material of the population cohort of the international project HAPIEE (Novosibirsk). The design of the study is «case-control». Random groups of women aged 55-84 with and without DM2 were formed in combination with the presence or absence of fractures in the history (n = 103, group 4). Standardized questionnaires, anthropometry, densitometry (dual energy X-ray absorptiometry, DEXA), TBI and FRAX® fracture risk determination were performed on all people.Results. Women with DM2 who reported a history fracture (group 1) had lower T-criteria in the femoral neck than women with DM2 without fracture (group 2), p = 0.039. However, the history of fracture in women with DM2 was accompanied by higher T-criteria values (by 0.3-0.5 SD) in the vertebrae and hips compared to women without DM (group 3). We did not get a significant difference in the TBI parameter between all 4 groups studied. We also found no difference in the risk of repeated fracture among women with and without DM2 using FRAX® without densitometry and TBI-adjusted FRAX® (p = 0.841, p = 0.094, respectively). In group 1 with DM2 and fractures, the risk for FRAX with T-test was lower than in group 3 without DM with fractures (p = 0.034 for the main fractures, p = 0.002 for the hip).Conclusion. In the studied population groups «case-control» of women aged 55-84 years with diabetes mellitus and fractures in their history, the risk of FRAX® fractures is lower with regard to DEXA and does not differ significantly in terms of TBI in comparison with women without DM2 fractures. The data obtained reflect the difficulties in diagnostics and the need to search for additional methods of early diagnosis of increased risk of fractures in patients with DM2. |
| first_indexed | 2024-04-09T16:43:36Z |
| format | Article |
| id | doaj.art-78efb8c6a70b480ca3acd9aeacb80165 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:43:36Z |
| publishDate | 2019-08-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-78efb8c6a70b480ca3acd9aeacb801652023-04-23T06:56:34ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-08-0104626810.21518/2079-701X-2019-4-62-68302510-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitusE. S. Mazurenko0O. D. Rymar1L. V. Scherbakova2Y. V. Khrapova3M. P. Isayeva4I. V. Munts5J. Hubacek6M. Bobak7S. K. Malutina8Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution «Federal Research Center «Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»; Federal State Budgetary Institution «Novosibirsk Scientific Research Institute of Traumatology and Orthopaedics named after Ya. L. Tsivyan» of the Ministry of Health of the Russian FederationResearch Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesResearch Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesFederal State Budgetary Institution «Novosibirsk Scientific Research Institute of Traumatology and Orthopaedics named after Ya.L. Tsivyan» of the Ministry of Health of the Russian FederationFederal State Autonomous Educational Institution of Higher Education Novosibirsk National Research State UniversityFederal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian FederationInstitute for Clinical and Experimental MedicineUniversity CollegeResearch Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution «Federal Research Center «Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»; Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian FederationThe aim of the study was to assess the 10-year risk of fractures (FRAX®), taking into account the values of bone mineral density (BMD) and trabecular bone index (TBI) in a population sample of women over 55 years of age with type 2 diabetes mellitus (DM2).Materials and methods. The study was carried out on the material of the population cohort of the international project HAPIEE (Novosibirsk). The design of the study is «case-control». Random groups of women aged 55-84 with and without DM2 were formed in combination with the presence or absence of fractures in the history (n = 103, group 4). Standardized questionnaires, anthropometry, densitometry (dual energy X-ray absorptiometry, DEXA), TBI and FRAX® fracture risk determination were performed on all people.Results. Women with DM2 who reported a history fracture (group 1) had lower T-criteria in the femoral neck than women with DM2 without fracture (group 2), p = 0.039. However, the history of fracture in women with DM2 was accompanied by higher T-criteria values (by 0.3-0.5 SD) in the vertebrae and hips compared to women without DM (group 3). We did not get a significant difference in the TBI parameter between all 4 groups studied. We also found no difference in the risk of repeated fracture among women with and without DM2 using FRAX® without densitometry and TBI-adjusted FRAX® (p = 0.841, p = 0.094, respectively). In group 1 with DM2 and fractures, the risk for FRAX with T-test was lower than in group 3 without DM with fractures (p = 0.034 for the main fractures, p = 0.002 for the hip).Conclusion. In the studied population groups «case-control» of women aged 55-84 years with diabetes mellitus and fractures in their history, the risk of FRAX® fractures is lower with regard to DEXA and does not differ significantly in terms of TBI in comparison with women without DM2 fractures. The data obtained reflect the difficulties in diagnostics and the need to search for additional methods of early diagnosis of increased risk of fractures in patients with DM2.https://www.med-sovet.pro/jour/article/view/3117diabetes mellitusosteoporosisfraxtrabecular bone indexdensitometry |
| spellingShingle | E. S. Mazurenko O. D. Rymar L. V. Scherbakova Y. V. Khrapova M. P. Isayeva I. V. Munts J. Hubacek M. Bobak S. K. Malutina 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus Медицинский совет diabetes mellitus osteoporosis frax trabecular bone index densitometry |
| title | 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| title_full | 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| title_fullStr | 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| title_full_unstemmed | 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| title_short | 10-year fracture risk (FRAX®), mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| title_sort | 10 year fracture risk frax r mineral bone density and trabecular bone index in women with type 2 diabetes mellitus |
| topic | diabetes mellitus osteoporosis frax trabecular bone index densitometry |
| url | https://www.med-sovet.pro/jour/article/view/3117 |
| work_keys_str_mv | AT esmazurenko 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT odrymar 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT lvscherbakova 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT yvkhrapova 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT mpisayeva 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT ivmunts 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT jhubacek 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT mbobak 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus AT skmalutina 10yearfractureriskfraxmineralbonedensityandtrabecularboneindexinwomenwithtype2diabetesmellitus |