Material Transport Characteristics in Planetary Roller Melt Granulation
Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2039 |
| _version_ | 1827728915219611648 |
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| author | Tom Lang Andreas Bramböck Markus Thommes Jens Bartsch |
| author_facet | Tom Lang Andreas Bramböck Markus Thommes Jens Bartsch |
| author_sort | Tom Lang |
| collection | DOAJ |
| description | Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing. |
| first_indexed | 2024-03-10T23:39:36Z |
| format | Article |
| id | doaj.art-78f61c34d9084931801b6cd6dfb5f91e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:36Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-78f61c34d9084931801b6cd6dfb5f91e2023-11-19T02:35:47ZengMDPI AGPharmaceutics1999-49232023-07-01158203910.3390/pharmaceutics15082039Material Transport Characteristics in Planetary Roller Melt GranulationTom Lang0Andreas Bramböck1Markus Thommes2Jens Bartsch3Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyMeltPrep GmbH, 8020 Graz, AustriaLaboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyLaboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyMelt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current research in pharmaceutical technology aims for continuous methods, as these have an enhanced potential to reduce product quality fluctuations. Concerning both aspects, the use of a planetary roller granulator is consequential. The process control with these machines benefits from the enhanced ratio of heated surface to processed volume, compared to the usually-applied twin-screw systems. This is related to the unique concept of planetary spindles flowing around a central spindle in a roller cylinder. Herein, the movement pattern defines the transport characteristics, which determine the energy input and overall processing conditions. The aim of this study is to investigate the residence time distribution in planetary roller melt granulation (PRMG) as an indicator for the material transport. By altering feed rate and rotation speed, the fill level in the granulator is adjusted, which directly affects the average transport velocity and mixing volume. The two-compartment model was utilized to reflect these coherences, as the model parameters symbolize the sub-processes of axial material transport and mixing.https://www.mdpi.com/1999-4923/15/8/2039continuous melt granulationplanetary roller granulatorresidence time distribution |
| spellingShingle | Tom Lang Andreas Bramböck Markus Thommes Jens Bartsch Material Transport Characteristics in Planetary Roller Melt Granulation Pharmaceutics continuous melt granulation planetary roller granulator residence time distribution |
| title | Material Transport Characteristics in Planetary Roller Melt Granulation |
| title_full | Material Transport Characteristics in Planetary Roller Melt Granulation |
| title_fullStr | Material Transport Characteristics in Planetary Roller Melt Granulation |
| title_full_unstemmed | Material Transport Characteristics in Planetary Roller Melt Granulation |
| title_short | Material Transport Characteristics in Planetary Roller Melt Granulation |
| title_sort | material transport characteristics in planetary roller melt granulation |
| topic | continuous melt granulation planetary roller granulator residence time distribution |
| url | https://www.mdpi.com/1999-4923/15/8/2039 |
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