Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2017-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170139 |
| _version_ | 1819263116468289536 |
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| author | Ana Ribeiro Joana F. Monteiro Ana C. Certal Ana M. Cristovão Leonor Saúde |
| author_facet | Ana Ribeiro Joana F. Monteiro Ana C. Certal Ana M. Cristovão Leonor Saúde |
| author_sort | Ana Ribeiro |
| collection | DOAJ |
| description | Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure. Finally, this study reveals that Foxj1a expression in the injured spinal cord is regulated by regulatory elements activated during regeneration. These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury. |
| first_indexed | 2024-12-23T20:08:28Z |
| format | Article |
| id | doaj.art-78f7cea1eebf40c6bb974d4076093b5a |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-23T20:08:28Z |
| publishDate | 2017-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-78f7cea1eebf40c6bb974d4076093b5a2022-12-21T17:32:53ZengThe Royal SocietyOpen Biology2046-24412017-01-0171110.1098/rsob.170139170139Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafishAna RibeiroJoana F. MonteiroAna C. CertalAna M. CristovãoLeonor SaúdeZebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure. Finally, this study reveals that Foxj1a expression in the injured spinal cord is regulated by regulatory elements activated during regeneration. These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170139foxj1ashhependymal radial gliacsf-contacting neuronsspinal cord injuryzebrafish |
| spellingShingle | Ana Ribeiro Joana F. Monteiro Ana C. Certal Ana M. Cristovão Leonor Saúde Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish Open Biology foxj1a shh ependymal radial glia csf-contacting neurons spinal cord injury zebrafish |
| title | Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| title_full | Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| title_fullStr | Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| title_full_unstemmed | Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| title_short | Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| title_sort | foxj1a is expressed in ependymal precursors controls central canal position and is activated in new ependymal cells during regeneration in zebrafish |
| topic | foxj1a shh ependymal radial glia csf-contacting neurons spinal cord injury zebrafish |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170139 |
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