Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems
Therapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/3/65 |
| _version_ | 1827713987283779584 |
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| author | Francesco Baino Saeid Kargozar |
| author_facet | Francesco Baino Saeid Kargozar |
| author_sort | Francesco Baino |
| collection | DOAJ |
| description | Therapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be properly modulated and designed in order to produce a therapeutic effect. An ideal ocular DDS should encapsulate and release the appropriate drug concentration to the target tissue (therapeutic but non-toxic level) while preserving drug functionality. Furthermore, a constant release is usually preferred, keeping the initial burst to a minimum. Different materials are used, modified, and combined in order to achieve a sustained drug release in both the anterior and posterior segments of the eye. After giving a picture of the different strategies adopted for ocular drug release, this review article provides an overview of the biomaterials that are used as drug carriers in the eye, including micro- and nanospheres, liposomes, hydrogels, and multi-material implants; the advantages and limitations of these DDSs are discussed in reference to the major ocular applications. |
| first_indexed | 2024-03-10T18:47:32Z |
| format | Article |
| id | doaj.art-78f8532488f64eb4867a51ba5fe81daf |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T18:47:32Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-78f8532488f64eb4867a51ba5fe81daf2023-11-20T05:22:23ZengMDPI AGBioengineering2306-53542020-06-01736510.3390/bioengineering7030065Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery SystemsFrancesco Baino0Saeid Kargozar1Department of Applied Science and Technology, Institute of Materials Physics and Engineering, Politecnico di Torino, 10129 Turin, ItalyTissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, IranTherapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be properly modulated and designed in order to produce a therapeutic effect. An ideal ocular DDS should encapsulate and release the appropriate drug concentration to the target tissue (therapeutic but non-toxic level) while preserving drug functionality. Furthermore, a constant release is usually preferred, keeping the initial burst to a minimum. Different materials are used, modified, and combined in order to achieve a sustained drug release in both the anterior and posterior segments of the eye. After giving a picture of the different strategies adopted for ocular drug release, this review article provides an overview of the biomaterials that are used as drug carriers in the eye, including micro- and nanospheres, liposomes, hydrogels, and multi-material implants; the advantages and limitations of these DDSs are discussed in reference to the major ocular applications.https://www.mdpi.com/2306-5354/7/3/65ocular biomaterialsdrug deliverypolymerscell-biomaterial interaction |
| spellingShingle | Francesco Baino Saeid Kargozar Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems Bioengineering ocular biomaterials drug delivery polymers cell-biomaterial interaction |
| title | Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems |
| title_full | Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems |
| title_fullStr | Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems |
| title_full_unstemmed | Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems |
| title_short | Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems |
| title_sort | regulation of the ocular cell tissue response by implantable biomaterials and drug delivery systems |
| topic | ocular biomaterials drug delivery polymers cell-biomaterial interaction |
| url | https://www.mdpi.com/2306-5354/7/3/65 |
| work_keys_str_mv | AT francescobaino regulationoftheocularcelltissueresponsebyimplantablebiomaterialsanddrugdeliverysystems AT saeidkargozar regulationoftheocularcelltissueresponsebyimplantablebiomaterialsanddrugdeliverysystems |