Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study
Plain English summary Anorexia nervosa is a serious psychosomatic disorder with increasing incidence worldwide. Numerous general medical complications affecting most major organ systems are caused by progressive malnutrition and rapid weight loss. However, precise pathomechanism involved in the path...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Journal of Eating Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40337-021-00408-6 |
| _version_ | 1797936462450130944 |
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| author | Alexandra Gaál Kovalčíková Ľubica Tichá Katarína Šebeková Peter Celec Alžbeta Čagalová Fatma Sogutlu Ľudmila Podracká |
| author_facet | Alexandra Gaál Kovalčíková Ľubica Tichá Katarína Šebeková Peter Celec Alžbeta Čagalová Fatma Sogutlu Ľudmila Podracká |
| author_sort | Alexandra Gaál Kovalčíková |
| collection | DOAJ |
| description | Plain English summary Anorexia nervosa is a serious psychosomatic disorder with increasing incidence worldwide. Numerous general medical complications affecting most major organ systems are caused by progressive malnutrition and rapid weight loss. However, precise pathomechanism involved in the pathogenesis of anorexia nervosa remains to be elucidated. A potential role of oxidative stress caused by metabolic disruption in the etiology of anorexia nervosa was already described in plasma or blood components. This study aimed to investigate whether redox imbalance could be detected even in alternative body fluids of patients with anorexia nervosa - urine and saliva. Samples from female patients (n = 111) with anorexia nervosa and healthy controls (n = 29) were collected and analysed in this study. Our results indicated that changes in redox homeostasis could be detected not only in plasma, but also in urine and saliva of patients with anorexia nervosa. This was shown by higher markers of oxidative stress - advanced oxidation protein products, fructosamines and advanced glycation end-products. Oxidative damage of biomolecules might have direct cytotoxic effect associated with increased expression of proinflammatory cytokines, growth factors etc. Thus, many medical complications of anorexia nervosa might be directly connected to the accumulation of oxidatively damaged biomolecules. |
| first_indexed | 2024-04-10T18:31:01Z |
| format | Article |
| id | doaj.art-78f88bfbc2d34c7eba863e9d1992927b |
| institution | Directory Open Access Journal |
| issn | 2050-2974 |
| language | English |
| last_indexed | 2024-04-10T18:31:01Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Eating Disorders |
| spelling | doaj.art-78f88bfbc2d34c7eba863e9d1992927b2023-02-02T04:18:06ZengBMCJournal of Eating Disorders2050-29742021-04-019111210.1186/s40337-021-00408-6Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional studyAlexandra Gaál Kovalčíková0Ľubica Tichá1Katarína Šebeková2Peter Celec3Alžbeta Čagalová4Fatma Sogutlu5Ľudmila Podracká6Department of Paediatrics, The National Institute of Children’s Diseases and Faculty of Medicine, Comenius UniversityDepartment of Paediatrics, The National Institute of Children’s Diseases and Faculty of Medicine, Comenius UniversityInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius UniversityInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius UniversityDepartment of Paediatrics, The National Institute of Children’s Diseases and Faculty of Medicine, Comenius UniversityDepartment of Medical Biology, Faculty of Medicine, Ege UniversityDepartment of Paediatrics, The National Institute of Children’s Diseases and Faculty of Medicine, Comenius UniversityPlain English summary Anorexia nervosa is a serious psychosomatic disorder with increasing incidence worldwide. Numerous general medical complications affecting most major organ systems are caused by progressive malnutrition and rapid weight loss. However, precise pathomechanism involved in the pathogenesis of anorexia nervosa remains to be elucidated. A potential role of oxidative stress caused by metabolic disruption in the etiology of anorexia nervosa was already described in plasma or blood components. This study aimed to investigate whether redox imbalance could be detected even in alternative body fluids of patients with anorexia nervosa - urine and saliva. Samples from female patients (n = 111) with anorexia nervosa and healthy controls (n = 29) were collected and analysed in this study. Our results indicated that changes in redox homeostasis could be detected not only in plasma, but also in urine and saliva of patients with anorexia nervosa. This was shown by higher markers of oxidative stress - advanced oxidation protein products, fructosamines and advanced glycation end-products. Oxidative damage of biomolecules might have direct cytotoxic effect associated with increased expression of proinflammatory cytokines, growth factors etc. Thus, many medical complications of anorexia nervosa might be directly connected to the accumulation of oxidatively damaged biomolecules.https://doi.org/10.1186/s40337-021-00408-6Eating disorderMalnutritionOxidative statusAntioxidantsBiomarkers |
| spellingShingle | Alexandra Gaál Kovalčíková Ľubica Tichá Katarína Šebeková Peter Celec Alžbeta Čagalová Fatma Sogutlu Ľudmila Podracká Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study Journal of Eating Disorders Eating disorder Malnutrition Oxidative status Antioxidants Biomarkers |
| title | Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study |
| title_full | Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study |
| title_fullStr | Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study |
| title_full_unstemmed | Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study |
| title_short | Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study |
| title_sort | oxidative status in plasma urine and saliva of girls with anorexia nervosa and healthy controls a cross sectional study |
| topic | Eating disorder Malnutrition Oxidative status Antioxidants Biomarkers |
| url | https://doi.org/10.1186/s40337-021-00408-6 |
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