Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2019.1621649 |
| _version_ | 1811337141067710464 |
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| author | Marco Alfio Cutuli Giulio Petronio Petronio Franca Vergalito Irene Magnifico Laura Pietrangelo Noemi Venditti Roberto Di Marco |
| author_facet | Marco Alfio Cutuli Giulio Petronio Petronio Franca Vergalito Irene Magnifico Laura Pietrangelo Noemi Venditti Roberto Di Marco |
| author_sort | Marco Alfio Cutuli |
| collection | DOAJ |
| description | A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host. |
| first_indexed | 2024-04-13T17:50:34Z |
| format | Article |
| id | doaj.art-78f8c5f02fb444139c12e7f84c0d7afc |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-13T17:50:34Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-78f8c5f02fb444139c12e7f84c0d7afc2022-12-22T02:36:43ZengTaylor & Francis GroupVirulence2150-55942150-56082019-01-0110152754110.1080/21505594.2019.16216491621649Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testingMarco Alfio Cutuli0Giulio Petronio Petronio1Franca Vergalito2Irene Magnifico3Laura Pietrangelo4Noemi Venditti5Roberto Di Marco6Università degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleUniversità degli Studi del Molise Italy - III Ed PolifunzionaleA greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host.http://dx.doi.org/10.1080/21505594.2019.1621649galleria mellonellain vivo testantibacterial strategiesnovel drug discoveryalternative animal model |
| spellingShingle | Marco Alfio Cutuli Giulio Petronio Petronio Franca Vergalito Irene Magnifico Laura Pietrangelo Noemi Venditti Roberto Di Marco Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing Virulence galleria mellonella in vivo test antibacterial strategies novel drug discovery alternative animal model |
| title | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
| title_full | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
| title_fullStr | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
| title_full_unstemmed | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
| title_short | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
| title_sort | galleria mellonella as a consolidated in vivo model hosts new developments in antibacterial strategies and novel drug testing |
| topic | galleria mellonella in vivo test antibacterial strategies novel drug discovery alternative animal model |
| url | http://dx.doi.org/10.1080/21505594.2019.1621649 |
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