Anti-angiogenic collagen IV-derived peptide target engagement with αvβ3 and α5β1 in ocular neovascularization models

Anti-angiogenic collagen IV-derived peptide target engagement with αvβ3 and α5β1 in ocular neovascularization models

Summary: AXT107, a collagen-derived peptide that binds integrins αvβ3 and α5β1 with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization (NV) and vascular leakage. Immunohistochemical stainin...

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Bibliographic Details
Main Authors: Raquel Lima e Silva, Adam C. Mirando, Stephany Y. Tzeng, Jordan J. Green, Aleksander S. Popel, Niranjan B. Pandey, Peter A. Campochiaro
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001554

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223001554

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