Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and pathogenic infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). It manifests as reproductive disorders in sows and respiratory disorders in piglets. PRRSV infects swine herds with...
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MDPI AG
2024-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/3/553 |
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| author | Gan Li Yajie Zheng Qin Luo Yaohua Liang Hang Zhang Huiyang Sha Ruining Wang Weili Kong Mengmeng Zhao |
| author_facet | Gan Li Yajie Zheng Qin Luo Yaohua Liang Hang Zhang Huiyang Sha Ruining Wang Weili Kong Mengmeng Zhao |
| author_sort | Gan Li |
| collection | DOAJ |
| description | Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and pathogenic infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). It manifests as reproductive disorders in sows and respiratory disorders in piglets. PRRSV infects swine herds with symptoms such as abortions, stillbirths, and mummified fetuses in gestating sows. Piglets mainly experience abdominal respiration and respiratory symptoms. To date, the prevention of PRRS relies primarily on vaccination and the implementation of various preventive and control measures. Swine deaths caused by PRRS have resulted in significant economic losses to the pig industry worldwide. Non-structural protein 10 (NSP10) has helicase and adenosine triphosphatase (ATPase) activities that unwind DNA and RNA and play important roles in viral replication and transcription. Hence, it can be potentially used to develop novel reagents for the detection of PPRSV. This article reviews genetic variations, interaction with viral and host proteins, effects on PRRSV replication, immunomodulation, apoptosis, and viral virulence of NSP10, with the aim of providing a theoretical basis for the prevention and control of PRRS and drug development in the future. |
| first_indexed | 2024-04-24T17:59:26Z |
| format | Article |
| id | doaj.art-78fdebd2d24949898bddb1cdfc17a268 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-24T17:59:26Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-78fdebd2d24949898bddb1cdfc17a2682024-03-27T13:55:48ZengMDPI AGMicroorganisms2076-26072024-03-0112355310.3390/microorganisms12030553Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome VirusGan Li0Yajie Zheng1Qin Luo2Yaohua Liang3Hang Zhang4Huiyang Sha5Ruining Wang6Weili Kong7Mengmeng Zhao8School of Life Science and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Science and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Science and Engineering, Foshan University, Foshan 528225, ChinaDepartment of Agricultural and Biosystems Engineering, South Dakota State University, Brookings, SD 57007, USASchool of Life Science and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Science and Engineering, Foshan University, Foshan 528225, ChinaCollege of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, ChinaGladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USASchool of Life Science and Engineering, Foshan University, Foshan 528225, ChinaPorcine reproductive and respiratory syndrome (PRRS) is a highly contagious and pathogenic infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). It manifests as reproductive disorders in sows and respiratory disorders in piglets. PRRSV infects swine herds with symptoms such as abortions, stillbirths, and mummified fetuses in gestating sows. Piglets mainly experience abdominal respiration and respiratory symptoms. To date, the prevention of PRRS relies primarily on vaccination and the implementation of various preventive and control measures. Swine deaths caused by PRRS have resulted in significant economic losses to the pig industry worldwide. Non-structural protein 10 (NSP10) has helicase and adenosine triphosphatase (ATPase) activities that unwind DNA and RNA and play important roles in viral replication and transcription. Hence, it can be potentially used to develop novel reagents for the detection of PPRSV. This article reviews genetic variations, interaction with viral and host proteins, effects on PRRSV replication, immunomodulation, apoptosis, and viral virulence of NSP10, with the aim of providing a theoretical basis for the prevention and control of PRRS and drug development in the future.https://www.mdpi.com/2076-2607/12/3/553PRRSVNSP10helicasegenetic evolutionapoptosisviral virulence |
| spellingShingle | Gan Li Yajie Zheng Qin Luo Yaohua Liang Hang Zhang Huiyang Sha Ruining Wang Weili Kong Mengmeng Zhao Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus Microorganisms PRRSV NSP10 helicase genetic evolution apoptosis viral virulence |
| title | Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus |
| title_full | Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus |
| title_fullStr | Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus |
| title_full_unstemmed | Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus |
| title_short | Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory Syndrome Virus |
| title_sort | research progress on the nsp10 protein of porcine reproductive and respiratory syndrome virus |
| topic | PRRSV NSP10 helicase genetic evolution apoptosis viral virulence |
| url | https://www.mdpi.com/2076-2607/12/3/553 |
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