Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization
A brain tumor in the left hemisphere can decrease language laterality as assessed through fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3852 |
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| author | Lucía Manso-Ortega Laura De Frutos-Sagastuy Sandra Gisbert-Muñoz Noriko Salamon Joe Qiao Patricia Walshaw Ileana Quiñones Monika M. Połczyńska |
| author_facet | Lucía Manso-Ortega Laura De Frutos-Sagastuy Sandra Gisbert-Muñoz Noriko Salamon Joe Qiao Patricia Walshaw Ileana Quiñones Monika M. Połczyńska |
| author_sort | Lucía Manso-Ortega |
| collection | DOAJ |
| description | A brain tumor in the left hemisphere can decrease language laterality as assessed through fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if the disruption of the language hubs exclusively affects the macrostructural properties of the contralateral homologues or whether it affects both hemispheres. This study uses voxel-based morphometry applied to high-resolution MR T1-weighted MPRAGE images from 31 adult patients’ left hemisphere, which is dominant for language. Eighteen patients had brain tumors in the left hemisphere, and thirteen had tumors in the right hemisphere. A cohort of 71 healthy individuals matched with respect to age and sex was used as a baseline. We defined 10 ROIs per hemisphere involved in language function. Two separate repeated-measure ANOVAs were conducted with the volume per region as the dependent variable. For the patients, tumor lateralization (right versus left) served as a between-subject factor. The current study demonstrated that the presence of a brain tumor generates global volumetric changes affecting the left language regions and their contralateral homologues. These changes are mediated by the lateralization of the lesion. Our findings suggest that functional mechanisms are supported by the rearrangement of the grey matter. |
| first_indexed | 2024-03-11T00:30:26Z |
| format | Article |
| id | doaj.art-79003b9ab2da42e293a1043cc7f83c45 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:26Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-79003b9ab2da42e293a1043cc7f83c452023-11-18T22:42:17ZengMDPI AGCancers2072-66942023-07-011515385210.3390/cancers15153852Grey Matter Reshaping of Language-Related Regions Depends on Tumor LateralizationLucía Manso-Ortega0Laura De Frutos-Sagastuy1Sandra Gisbert-Muñoz2Noriko Salamon3Joe Qiao4Patricia Walshaw5Ileana Quiñones6Monika M. Połczyńska7Neurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, SpainNeurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, SpainNeurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, SpainDepartment of Radiology, University of California, Los Angeles, CA 92093, USADepartment of Radiology, University of California, Los Angeles, CA 92093, USADepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 92093, USANeurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, SpainDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 92093, USAA brain tumor in the left hemisphere can decrease language laterality as assessed through fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if the disruption of the language hubs exclusively affects the macrostructural properties of the contralateral homologues or whether it affects both hemispheres. This study uses voxel-based morphometry applied to high-resolution MR T1-weighted MPRAGE images from 31 adult patients’ left hemisphere, which is dominant for language. Eighteen patients had brain tumors in the left hemisphere, and thirteen had tumors in the right hemisphere. A cohort of 71 healthy individuals matched with respect to age and sex was used as a baseline. We defined 10 ROIs per hemisphere involved in language function. Two separate repeated-measure ANOVAs were conducted with the volume per region as the dependent variable. For the patients, tumor lateralization (right versus left) served as a between-subject factor. The current study demonstrated that the presence of a brain tumor generates global volumetric changes affecting the left language regions and their contralateral homologues. These changes are mediated by the lateralization of the lesion. Our findings suggest that functional mechanisms are supported by the rearrangement of the grey matter.https://www.mdpi.com/2072-6694/15/15/3852structural plasticityVBMbrain tumor patientslanguage network |
| spellingShingle | Lucía Manso-Ortega Laura De Frutos-Sagastuy Sandra Gisbert-Muñoz Noriko Salamon Joe Qiao Patricia Walshaw Ileana Quiñones Monika M. Połczyńska Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization Cancers structural plasticity VBM brain tumor patients language network |
| title | Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization |
| title_full | Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization |
| title_fullStr | Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization |
| title_full_unstemmed | Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization |
| title_short | Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization |
| title_sort | grey matter reshaping of language related regions depends on tumor lateralization |
| topic | structural plasticity VBM brain tumor patients language network |
| url | https://www.mdpi.com/2072-6694/15/15/3852 |
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