Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils
Essential oils are one of the most popular natural products, with broad applications in dermatology. Hair loss is a disorder in which the hair falls out from skin areas where they are usually present, such as the scalp and the body.The aim of the work was to formulate oleogels containing two essenti...
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Elsevier
2022-07-01
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| coleção: | Scientific African |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2468227622001302 |
| _version_ | 1828106649997410304 |
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| author | Emmanuel Uronnachi Chidiogo Atuegwu Chukwuebuka Umeyor Calistus Nwakile Josephat Obasi Chidalu Ikeotuonye Anthony Attama |
| author_facet | Emmanuel Uronnachi Chidiogo Atuegwu Chukwuebuka Umeyor Calistus Nwakile Josephat Obasi Chidalu Ikeotuonye Anthony Attama |
| author_sort | Emmanuel Uronnachi |
| collection | DOAJ |
| description | Essential oils are one of the most popular natural products, with broad applications in dermatology. Hair loss is a disorder in which the hair falls out from skin areas where they are usually present, such as the scalp and the body.The aim of the work was to formulate oleogels containing two essential oils (Cedarwood and Rosemary) singly and in combination and evaluate their hair growth enhancing effect on an animal model. Oleogels were formed using beeswax as the organogelator with concentrations of 10 % for the oils when used singly or 5 % each for the oils when formulated in combination. Characterization of oleogels were done using spreadability, oil binding capacity (OBC), gas chromatography (GC) and differential scanning calorimetry (DSC). Hair growth evaluation was carried out in 18 albino rats in six groups of threes. A hair removal cream was applied on the experimental animals and the Oleogel applied for six-weeks.GC analysis of the oils revealed the presence of thujopsene, alpha-pinene, beta-pinene, pentane, alpha cedrenea, beta cedrenea, alpha cedrol, gamma-terpene, acetonitrite, atlantone, terpinolene in cedarwood oil while rosemary oil contained 1-8 cineole, camphor, alpha-pinene, beta-pinene, camphene, p-cymene, alpha-terpinene, gamma terpinene, gamma-humulene, beat-bisabolene, genaniol and terpinolene. DSC thermogram of the oleogel formulations showed varying degrees of amorphicity.Spreadability results showed that the oleogels containing cedarwood oil were more spreadable. Conversely, oil binding capacity values were higher with Rosemary oil than Cedar wood oil with values ranging from 91 % (for the oleogel containing 10 % rosemary oil) to 81 % for the bland oleogel (no essential oil). Hair growth evaluation revealed that the oleogel containing rosemary oil (10 %) had similar effects as the positive control (Minoxidil, 2 %) at the end of the six-week period.Oleogels made from cedar wood and rosemary oils have hair growth enhancing effects. |
| first_indexed | 2024-04-11T10:20:35Z |
| format | Article |
| id | doaj.art-7900c2e5bd894c12b5b9016b51f1816d |
| institution | Directory Open Access Journal |
| issn | 2468-2276 |
| language | English |
| last_indexed | 2024-04-11T10:20:35Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Scientific African |
| spelling | doaj.art-7900c2e5bd894c12b5b9016b51f1816d2022-12-22T04:29:46ZengElsevierScientific African2468-22762022-07-0116e01223Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oilsEmmanuel Uronnachi0Chidiogo Atuegwu1Chukwuebuka Umeyor2Calistus Nwakile3Josephat Obasi4Chidalu Ikeotuonye5Anthony Attama6Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria; Corresponding author.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, NigeriaEssential oils are one of the most popular natural products, with broad applications in dermatology. Hair loss is a disorder in which the hair falls out from skin areas where they are usually present, such as the scalp and the body.The aim of the work was to formulate oleogels containing two essential oils (Cedarwood and Rosemary) singly and in combination and evaluate their hair growth enhancing effect on an animal model. Oleogels were formed using beeswax as the organogelator with concentrations of 10 % for the oils when used singly or 5 % each for the oils when formulated in combination. Characterization of oleogels were done using spreadability, oil binding capacity (OBC), gas chromatography (GC) and differential scanning calorimetry (DSC). Hair growth evaluation was carried out in 18 albino rats in six groups of threes. A hair removal cream was applied on the experimental animals and the Oleogel applied for six-weeks.GC analysis of the oils revealed the presence of thujopsene, alpha-pinene, beta-pinene, pentane, alpha cedrenea, beta cedrenea, alpha cedrol, gamma-terpene, acetonitrite, atlantone, terpinolene in cedarwood oil while rosemary oil contained 1-8 cineole, camphor, alpha-pinene, beta-pinene, camphene, p-cymene, alpha-terpinene, gamma terpinene, gamma-humulene, beat-bisabolene, genaniol and terpinolene. DSC thermogram of the oleogel formulations showed varying degrees of amorphicity.Spreadability results showed that the oleogels containing cedarwood oil were more spreadable. Conversely, oil binding capacity values were higher with Rosemary oil than Cedar wood oil with values ranging from 91 % (for the oleogel containing 10 % rosemary oil) to 81 % for the bland oleogel (no essential oil). Hair growth evaluation revealed that the oleogel containing rosemary oil (10 %) had similar effects as the positive control (Minoxidil, 2 %) at the end of the six-week period.Oleogels made from cedar wood and rosemary oils have hair growth enhancing effects.http://www.sciencedirect.com/science/article/pii/S2468227622001302OleogelorganogelatorRosemary oilCedarwood oilBeeswaxHair growth |
| spellingShingle | Emmanuel Uronnachi Chidiogo Atuegwu Chukwuebuka Umeyor Calistus Nwakile Josephat Obasi Chidalu Ikeotuonye Anthony Attama Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils Scientific African Oleogel organogelator Rosemary oil Cedarwood oil Beeswax Hair growth |
| title | Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils |
| title_full | Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils |
| title_fullStr | Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils |
| title_full_unstemmed | Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils |
| title_short | Formulation and evaluation of hair growth enhancing effects of oleogels made from Rosemary and Cedar wood oils |
| title_sort | formulation and evaluation of hair growth enhancing effects of oleogels made from rosemary and cedar wood oils |
| topic | Oleogel organogelator Rosemary oil Cedarwood oil Beeswax Hair growth |
| url | http://www.sciencedirect.com/science/article/pii/S2468227622001302 |
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