Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae

Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae

Nemonoxacin, a novel nonfluorinated quinolone for the treatment of community-acquired pneumonia. We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets and PK/PD breakpoints of nemonoxacin against Streptococcus pneumoniae using a neutropenic murine lung infection model. Single-dose PK analy...

Full description

Bibliographic Details
Main Authors:	Xin Li, Yuancheng Chen, Xiaoyong Xu, Yi Li, Yaxin Fan, Xiaofen Liu, Xingchen Bian, Hailan Wu, Xu Zhao, Meiqing Feng, Beining Guo, Jing Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Pharmacology
Subjects:	nemonoxacin pharmacokinetics/pharmacodynamics streptococcus pneumoniae neutropenic murine lung infection model breakpoint
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.658558/full

Similar Items

In vitro pharmacodynamics of nemonoxacin and other antimicrobial agents against Mycoplasma pneumoniae
by: Na Wang, et al.
Published: (2023-12-01)

Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis
by: Chuhan Zhang, et al.
Published: (2022-04-01)

Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla<sub>OXA-23</sub>-harboring CRAB in In Vitro PK/PD Model
by: Xingyi Qu, et al.
Published: (2022-02-01)

Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia
by: Yuancheng Chen, et al.
Published: (2023-02-01)

Pharmacokinetic/Pharmacodynamic Based Breakpoints of Polymyxin B for Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Pathogens
by: Xingchen Bian, et al.
Published: (2022-01-01)

Identification and Comparative Genomic Analysis of Type VI Secretion Systems and Effectors in Klebsiella pneumoniae
by: Wanzhen Li, et al.
Published: (2022-05-01)

Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance
by: Jinyi Yuan, et al.
Published: (2022-12-01)

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations
by: Yu Wang, et al.
Published: (2022-07-01)

In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms
by: Na Wang, et al.
Published: (2019-08-01)

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
by: Zhang YF, et al.
Published: (2016-01-01)

Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
by: Yaxin Fan, et al.
Published: (2022-06-01)

The efficacy and safety of nemonoxacin compared with levofloxacin in the treatment of community-acquired pneumonia: a systemic review and meta-analysis of randomized controlled trials
by: Chang SP, et al.
Published: (2019-02-01)

Activities of Eravacycline, Tedizolid, Norvancomycin, Nemonoxacin, Ceftaroline, and Comparators against 1,871 Staphylococcus and 1,068 Enterococcus Species Isolates from China: Updated Report of the CHINET Study 2019
by: Li Ding, et al.
Published: (2022-12-01)

Current Approach to Neutropenic Enterocolitis
by: Umran Sümeyse Ertürk, et al.
Published: (2020-04-01)

Correction to: epidemiological and genomic characteristics of A. baumannii from different infection sites using comparative genomics
by: Xingchen Bian, et al.
Published: (2021-09-01)

Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics
by: Xingchen Bian, et al.
Published: (2021-07-01)

In vitro pharmacokinetics/pharmacodynamics of FL058 (a novel beta-lactamase inhibitor) combined with meropenem against carbapenemase-producing Enterobacterales
by: Zhiwei Huang, et al.
Published: (2024-04-01)

A combination of genomics and transcriptomics provides insights into the distribution and differential mRNA expression of type VI secretion system in clinical Klebsiella pneumoniae
by: Wanzhen Li, et al.
Published: (2024-03-01)

Emergence of resistant Candida in neutropenic patients
by: Nucci Marcio, et al.
Published: (2002-01-01)

Safety and efficacy of nemonoxacin versus levofloxacin in the treatment of community-acquired pneumonia: results of phase III, multicenter, randomized, double-blind, active-controlled, non-inferiority trial
by: Kozlov R.S., et al.
Published: (2018-11-01)

Tentative clinical breakpoints and epidemiological cut-off values of nemonoxacin for Streptococcus pneumoniae and Staphylococcus aureus isolates associated with community-acquired pneumonia
by: Shio-Shin Jean, et al.
Published: (2020-12-01)

mNGS for identifying pathogens in febrile neutropenic children with hematological diseases
by: Fang Guo, et al.
Published: (2022-03-01)

Pharmacokinetics/pharmacodynamics of polymyxin B in patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae
by: Zhenwei Yu, et al.
Published: (2022-12-01)

Neutropenic Fever
by: Shannon Toohey
Published: (2016-09-01)

Evaluation of Factors Affecting Treatment Success in Febrile Neutropenic Cancer Patients
by: Gülay SAİN GÜVEN, et al.
Published: (2004-12-01)

Respiratory Viruses in Febrile Neutropenic Patients with Respiratory Symptoms
by: Mohsen Meidani, et al.
Published: (2018-01-01)

Candida infections among neutropenic patients
by: Rasoul Mohammadi, et al.
Published: (2016-04-01)

Acute fungal sinusitis in neutropenic patients of Namazi hospital/ Shiraz
by: Parisa Badiee, et al.
Published: (2008-09-01)

Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer
by: Xu Peng, et al.
Published: (2023-10-01)

Neutropenic Diet Cannot Reduce the Risk of Infection and Mortality in Oncology Patients With Neutropenia
by: Yimei Ma, et al.
Published: (2022-03-01)

The value of computerized tomography of the chest in patients with neutropenic fever
by: Khudhair A AL-Khalissi, et al.
Published: (2015-10-01)

Experience of ten years of neutropenic enterocolitis in intensive care at Instituto Nacional de Pediatría
by: Mireya Muñoz-Ramírez, et al.
Published: (2014-10-01)

Computerized tomography findings of neutropenic enterocolitis and its relationship with prognosis
by: Ali Mahir Gündüz, et al.
Published: (2021-04-01)

Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile
by: Giuseppe Bertozzi, et al.
Published: (2021-06-01)

Neoadjuvant Doxorubicin and Docetaxel in Breast Cancer Patients Applied Neutropenic Enterocolitis
by: Hatice Aslan Sırakaya, et al.
Published: (2020-01-01)

Nurse role in the prevention of infections of the oncology patient with fever neutropenic
by: Imilia Torres Orue, et al.
Published: (2011-01-01)

Early Diagnosis of Neutropenic Enterocolitis by Bedside Ultrasound in Hematological Malignancies: A Prospective Study
by: Edoardo Benedetti, et al.
Published: (2021-09-01)

Clostridium tertium in neutropenic patients: case series at a cancer institute
by: Sweta Shah, et al.
Published: (2016-10-01)

Use of neutropenic diet in the nutritional care of pediatric cancer patients with neutropenia: a scoping review
by: Ana Paula Carvalho Arnhold, et al.
Published: (2024-03-01)

Proteomics Landscape of Host-Pathogen Interaction in Acinetobacter baumannii Infected Mouse Lung
by: Xin Li, et al.
Published: (2021-05-01)