MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
Abstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeuti...
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Format: | Article |
Language: | English |
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BMC
2021-01-01
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Series: | Cancer Cell International |
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Online Access: | https://doi.org/10.1186/s12935-020-01716-8 |
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author | Tong Niu Weiwei Zhang Wei Xiao |
author_facet | Tong Niu Weiwei Zhang Wei Xiao |
author_sort | Tong Niu |
collection | DOAJ |
description | Abstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance. |
first_indexed | 2024-12-14T12:34:03Z |
format | Article |
id | doaj.art-7901a7897e7048a7ba9c2d9d19cca1de |
institution | Directory Open Access Journal |
issn | 1475-2867 |
language | English |
last_indexed | 2024-12-14T12:34:03Z |
publishDate | 2021-01-01 |
publisher | BMC |
record_format | Article |
series | Cancer Cell International |
spelling | doaj.art-7901a7897e7048a7ba9c2d9d19cca1de2022-12-21T23:01:06ZengBMCCancer Cell International1475-28672021-01-0121111410.1186/s12935-020-01716-8MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancerTong Niu0Weiwei Zhang1Wei Xiao2Beijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityBeijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityBeijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityAbstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.https://doi.org/10.1186/s12935-020-01716-8Breast cancerBreast cancer stem cell (BCSC)miRNASelf-renewalTherapeutic resistance |
spellingShingle | Tong Niu Weiwei Zhang Wei Xiao MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer Cancer Cell International Breast cancer Breast cancer stem cell (BCSC) miRNA Self-renewal Therapeutic resistance |
title | MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer |
title_full | MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer |
title_fullStr | MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer |
title_full_unstemmed | MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer |
title_short | MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer |
title_sort | microrna regulation of cancer stem cells in the pathogenesis of breast cancer |
topic | Breast cancer Breast cancer stem cell (BCSC) miRNA Self-renewal Therapeutic resistance |
url | https://doi.org/10.1186/s12935-020-01716-8 |
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