MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer

Abstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeuti...

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Main Authors: Tong Niu, Weiwei Zhang, Wei Xiao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
Online Access:https://doi.org/10.1186/s12935-020-01716-8
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author Tong Niu
Weiwei Zhang
Wei Xiao
author_facet Tong Niu
Weiwei Zhang
Wei Xiao
author_sort Tong Niu
collection DOAJ
description Abstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.
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spelling doaj.art-7901a7897e7048a7ba9c2d9d19cca1de2022-12-21T23:01:06ZengBMCCancer Cell International1475-28672021-01-0121111410.1186/s12935-020-01716-8MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancerTong Niu0Weiwei Zhang1Wei Xiao2Beijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityBeijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityBeijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal UniversityAbstract Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.https://doi.org/10.1186/s12935-020-01716-8Breast cancerBreast cancer stem cell (BCSC)miRNASelf-renewalTherapeutic resistance
spellingShingle Tong Niu
Weiwei Zhang
Wei Xiao
MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
Cancer Cell International
Breast cancer
Breast cancer stem cell (BCSC)
miRNA
Self-renewal
Therapeutic resistance
title MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
title_full MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
title_fullStr MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
title_full_unstemmed MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
title_short MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
title_sort microrna regulation of cancer stem cells in the pathogenesis of breast cancer
topic Breast cancer
Breast cancer stem cell (BCSC)
miRNA
Self-renewal
Therapeutic resistance
url https://doi.org/10.1186/s12935-020-01716-8
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AT weiweizhang micrornaregulationofcancerstemcellsinthepathogenesisofbreastcancer
AT weixiao micrornaregulationofcancerstemcellsinthepathogenesisofbreastcancer