Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System
Cryptosporidiosis is caused by an opportunistic protozoan parasite (<i>Cryptosporidium parvum</i> and <i>C. hominis</i>) known as a parasite of humans, especially children and immunocompromised patients. The current study was designed to evaluate the therapeutic efficacy of a...
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2021-09-01
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| author | Wafaa Fayez Abd El-Hamed Nahed Samy Yousef Yasser S. A. Mazrou Walaa A. E. S. Elkholy Amal I. El-Refaiy Faten A. Elfeky Muayad Albadrani Ahmed I. El-Tokhy Khaled Abdelaal |
| author_facet | Wafaa Fayez Abd El-Hamed Nahed Samy Yousef Yasser S. A. Mazrou Walaa A. E. S. Elkholy Amal I. El-Refaiy Faten A. Elfeky Muayad Albadrani Ahmed I. El-Tokhy Khaled Abdelaal |
| author_sort | Wafaa Fayez Abd El-Hamed |
| collection | DOAJ |
| description | Cryptosporidiosis is caused by an opportunistic protozoan parasite (<i>Cryptosporidium parvum</i> and <i>C. hominis</i>) known as a parasite of humans, especially children and immunocompromised patients. The current study was designed to evaluate the therapeutic efficacy of a mixture of fig and olive leaf extracts as an alternative medicinal plant. Parasitological examination for oocysts in the stool and histopathological alterations in the small intestines were examined. Additionally, biochemical analyses of liver and kidney functions in addition to antioxidant parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH) and catalase (CAT) in the plasma were evaluated. Our results showed that marked reduction in oocysts shedding and amelioration in intestinal histopathological changes and hepatic or renal functions were detected in all treated groups compared to the control infected group. Additionally, the treated groups with tested extracts at ratios 1:3 and 1:5 showed a significant decrease in the number of oocysts compared to the other treated groups. Results exhibited a significant increase in the plasma SOD, CAT and GSH levels in treated groups compared to the infected control one. This study suggested that a mixture of fig and olive leaf extracts is a convenient promising therapeutic agent for Cryptosporidiosis. |
| first_indexed | 2024-03-10T07:48:26Z |
| format | Article |
| id | doaj.art-790219bc147346be9274735b4c78d454 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:26Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-790219bc147346be9274735b4c78d4542023-11-22T12:25:53ZengMDPI AGCells2073-44092021-09-01109241910.3390/cells10092419Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative SystemWafaa Fayez Abd El-Hamed0Nahed Samy Yousef1Yasser S. A. Mazrou2Walaa A. E. S. Elkholy3Amal I. El-Refaiy4Faten A. Elfeky5Muayad Albadrani6Ahmed I. El-Tokhy7Khaled Abdelaal8Biological and Environmental Sciences Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptFood Science and Technology Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptBusiness Administration Department, Community College, King Khalid University, Guraiger, Abha 62529, Saudi ArabiaDepartment of Parasitology, Faculty of Medicine Al-Azhar University, Tanta 11754, EgyptBiological and Environmental Sciences Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptZoology Department, Faculty of Science (Girls), Al-Azhar University, Tanta 11754, EgyptDepartment of Family and Community Medicine, College of Medicine, Taibah University, Madinah 41541, Saudi ArabiaPlant Protection Department, Faculty of Agriculture, New Valley University, El-Kharga 72511, EgyptExcellence Center (EPCRS), Plant Pathology and Biotechnology Laboratory, Faculty of Agriculture, Kafrelsheikh University, Kafr Elsheikh 33516, EgyptCryptosporidiosis is caused by an opportunistic protozoan parasite (<i>Cryptosporidium parvum</i> and <i>C. hominis</i>) known as a parasite of humans, especially children and immunocompromised patients. The current study was designed to evaluate the therapeutic efficacy of a mixture of fig and olive leaf extracts as an alternative medicinal plant. Parasitological examination for oocysts in the stool and histopathological alterations in the small intestines were examined. Additionally, biochemical analyses of liver and kidney functions in addition to antioxidant parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH) and catalase (CAT) in the plasma were evaluated. Our results showed that marked reduction in oocysts shedding and amelioration in intestinal histopathological changes and hepatic or renal functions were detected in all treated groups compared to the control infected group. Additionally, the treated groups with tested extracts at ratios 1:3 and 1:5 showed a significant decrease in the number of oocysts compared to the other treated groups. Results exhibited a significant increase in the plasma SOD, CAT and GSH levels in treated groups compared to the infected control one. This study suggested that a mixture of fig and olive leaf extracts is a convenient promising therapeutic agent for Cryptosporidiosis.https://www.mdpi.com/2073-4409/10/9/2419cryptosporidiosisenzymes activityoocystnitazoxanidefig and olive leave extractsoxidative stress |
| spellingShingle | Wafaa Fayez Abd El-Hamed Nahed Samy Yousef Yasser S. A. Mazrou Walaa A. E. S. Elkholy Amal I. El-Refaiy Faten A. Elfeky Muayad Albadrani Ahmed I. El-Tokhy Khaled Abdelaal Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System Cells cryptosporidiosis enzymes activity oocyst nitazoxanide fig and olive leave extracts oxidative stress |
| title | Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System |
| title_full | Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System |
| title_fullStr | Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System |
| title_full_unstemmed | Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System |
| title_short | Anticryptosporidium Efficacy of <i>Olea europaea</i> and <i>Ficus carica</i> Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System |
| title_sort | anticryptosporidium efficacy of i olea europaea i and i ficus carica i leaves extract in immunocompromised mice associated with biochemical characters and antioxidative system |
| topic | cryptosporidiosis enzymes activity oocyst nitazoxanide fig and olive leave extracts oxidative stress |
| url | https://www.mdpi.com/2073-4409/10/9/2419 |
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