A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding
Mitra Corral,1 Nicole Ferko,2 Andrew Hogan,2 Sarah S Hollmann,2 Gaurav Gangoli,1 Nadine Jamous,3 Jonathan Batiller,1 Richard Kocharian1 1Ethicon BioSurgery, Somerville, NJ, USA; 2Cornerstone Research Group, Burlington, ON, Canada; 3Ethicon Biosurgery, Wokingham, Berkshire, UK Background: Despite hem...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-09-01
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| Series: | ClinicoEconomics and Outcomes Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-hospital-cost-analysis-of-a-fibrin-sealant-patch-in-soft-tissue-and--peer-reviewed-article-CEOR |
| _version_ | 1818057485837139968 |
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| author | Corral M Ferko N Hogan A Hollmann SS Gangoli G Jamous N Batiller J Kocharian R |
| author_facet | Corral M Ferko N Hogan A Hollmann SS Gangoli G Jamous N Batiller J Kocharian R |
| author_sort | Corral M |
| collection | DOAJ |
| description | Mitra Corral,1 Nicole Ferko,2 Andrew Hogan,2 Sarah S Hollmann,2 Gaurav Gangoli,1 Nadine Jamous,3 Jonathan Batiller,1 Richard Kocharian1 1Ethicon BioSurgery, Somerville, NJ, USA; 2Cornerstone Research Group, Burlington, ON, Canada; 3Ethicon Biosurgery, Wokingham, Berkshire, UK Background: Despite hemostat use, uncontrolled surgical bleeding is prevalent. Drawbacks of current hemostats include limitations with efficacy on first attempt and suboptimal ease-of-use. Evarrest® is a novel fibrin sealant patch that has demonstrated high hemostatic efficacy compared with standard of care across bleeding severities. The objective of this study was to conduct a hospital cost analysis of the fibrin sealant patch versus standard of care in soft tissue and hepatic surgical bleeding. Methods: The analysis quantified the 30-day costs of each comparator from a hospital perspective. Published US unit costs were applied to resource use (ie, initial treatment, retreatment, operating time, hospitalization, transfusion, and ventilator) reported in four trials. A “surgical” analysis included resources clinically related to the hemostatic benefit of the fibrin sealant patch, whereas a “hospital” analysis included all resources reported in the trials. An exploratory subgroup analysis focused solely on coagulopathic patients defined by abnormal blood test results. Results: The surgical analysis predicted cost savings of $54 per patient with the fibrin sealant patch compared with standard of care (net cost impact: −$54 per patient; sensitivity range: −$1,320 to $1,213). The hospital analysis predicted further cost savings with the fibrin sealant patch (net cost impact of −$2,846 per patient; sensitivity range: −$1,483 to −$5,575). Subgroup analyses suggest that the fibrin sealant patch may provide dramatic cost savings in the coagulopathic subgroup of $3,233 (surgical) and $9,287 (hospital) per patient. Results were most sensitive to operating time and product units. Conclusion: In soft tissue and hepatic problematic surgical bleeding, the fibrin sealant patch may result in important hospital cost savings. Keywords: cost, soft tissue bleeding, hepatic bleeding, surgical bleeding, coagulopathic, fibrin sealant patch, hospital, health economics |
| first_indexed | 2024-12-10T12:45:29Z |
| format | Article |
| id | doaj.art-79035bee5070413e83525038aa3af1d6 |
| institution | Directory Open Access Journal |
| issn | 1178-6981 |
| language | English |
| last_indexed | 2024-12-10T12:45:29Z |
| publishDate | 2016-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | ClinicoEconomics and Outcomes Research |
| spelling | doaj.art-79035bee5070413e83525038aa3af1d62022-12-22T01:48:24ZengDove Medical PressClinicoEconomics and Outcomes Research1178-69812016-09-01Volume 850751929038A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleedingCorral MFerko NHogan AHollmann SSGangoli GJamous NBatiller JKocharian RMitra Corral,1 Nicole Ferko,2 Andrew Hogan,2 Sarah S Hollmann,2 Gaurav Gangoli,1 Nadine Jamous,3 Jonathan Batiller,1 Richard Kocharian1 1Ethicon BioSurgery, Somerville, NJ, USA; 2Cornerstone Research Group, Burlington, ON, Canada; 3Ethicon Biosurgery, Wokingham, Berkshire, UK Background: Despite hemostat use, uncontrolled surgical bleeding is prevalent. Drawbacks of current hemostats include limitations with efficacy on first attempt and suboptimal ease-of-use. Evarrest® is a novel fibrin sealant patch that has demonstrated high hemostatic efficacy compared with standard of care across bleeding severities. The objective of this study was to conduct a hospital cost analysis of the fibrin sealant patch versus standard of care in soft tissue and hepatic surgical bleeding. Methods: The analysis quantified the 30-day costs of each comparator from a hospital perspective. Published US unit costs were applied to resource use (ie, initial treatment, retreatment, operating time, hospitalization, transfusion, and ventilator) reported in four trials. A “surgical” analysis included resources clinically related to the hemostatic benefit of the fibrin sealant patch, whereas a “hospital” analysis included all resources reported in the trials. An exploratory subgroup analysis focused solely on coagulopathic patients defined by abnormal blood test results. Results: The surgical analysis predicted cost savings of $54 per patient with the fibrin sealant patch compared with standard of care (net cost impact: −$54 per patient; sensitivity range: −$1,320 to $1,213). The hospital analysis predicted further cost savings with the fibrin sealant patch (net cost impact of −$2,846 per patient; sensitivity range: −$1,483 to −$5,575). Subgroup analyses suggest that the fibrin sealant patch may provide dramatic cost savings in the coagulopathic subgroup of $3,233 (surgical) and $9,287 (hospital) per patient. Results were most sensitive to operating time and product units. Conclusion: In soft tissue and hepatic problematic surgical bleeding, the fibrin sealant patch may result in important hospital cost savings. Keywords: cost, soft tissue bleeding, hepatic bleeding, surgical bleeding, coagulopathic, fibrin sealant patch, hospital, health economicshttps://www.dovepress.com/a-hospital-cost-analysis-of-a-fibrin-sealant-patch-in-soft-tissue-and--peer-reviewed-article-CEORcostsoft tissue bleedinghepatic bleedingsurgical bleedingcoagulopathicfibrin sealant patchhospital |
| spellingShingle | Corral M Ferko N Hogan A Hollmann SS Gangoli G Jamous N Batiller J Kocharian R A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding ClinicoEconomics and Outcomes Research cost soft tissue bleeding hepatic bleeding surgical bleeding coagulopathic fibrin sealant patch hospital |
| title | A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| title_full | A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| title_fullStr | A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| title_full_unstemmed | A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| title_short | A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| title_sort | hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding |
| topic | cost soft tissue bleeding hepatic bleeding surgical bleeding coagulopathic fibrin sealant patch hospital |
| url | https://www.dovepress.com/a-hospital-cost-analysis-of-a-fibrin-sealant-patch-in-soft-tissue-and--peer-reviewed-article-CEOR |
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