Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
Abstract Background Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. Methods Data of 1,376,540 participant...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01030-z |
| _version_ | 1797836357354127360 |
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| author | Min-Kyung Lee Jae-Hyuk Lee Seo Young Sohn Jiyeon Ahn Oak-Kee Hong Mee-Kyoung Kim Ki-Hyun Baek Ki-Ho Song Kyungdo Han Hyuk-Sang Kwon |
| author_facet | Min-Kyung Lee Jae-Hyuk Lee Seo Young Sohn Jiyeon Ahn Oak-Kee Hong Mee-Kyoung Kim Ki-Hyun Baek Ki-Ho Song Kyungdo Han Hyuk-Sang Kwon |
| author_sort | Min-Kyung Lee |
| collection | DOAJ |
| description | Abstract Background Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. Methods Data of 1,376,540 participants aged 20–39 years without a history of type 2 diabetes and who underwent four annual health check-ups were collected. In this large-scale prospective cohort study, we evaluated the incidence rates and hazard ratios (HRs) of diabetes according to cumulative frequencies of metabolic syndrome over 4 years of consecutive annual health check-ups (burden score 0–4). Subgroup analyses were performed by sex and age. Results During 5.18 years of follow-up, 18,155 young adults developed type 2 diabetes. The incidence of type 2 diabetes increased with burden score (P < 0.0001). The multivariable-adjusted HRs for type 2 diabetes were 4.757, 10.511, 18.288, and 31.749 in participants with a burden score of 1 to 4, respectively, compared to those with 0. In subgroup analyses, the risk of incident diabetes was greater in women than men and in the 20–29 years age group than the 30–39 years age group. The HRs were 47.473 in women and 27.852 in men with four burden scores. Conclusion The risk of type 2 diabetes significantly increased with an increase in the cumulative burden of metabolic syndrome in young adults. Additionally, the association between cumulative burden and diabetes risk was stronger in women and the 20s age group. |
| first_indexed | 2024-04-09T15:07:30Z |
| format | Article |
| id | doaj.art-790519fb86b248a4b65cfcc4f3cf5c53 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-09T15:07:30Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-790519fb86b248a4b65cfcc4f3cf5c532023-04-30T11:22:53ZengBMCDiabetology & Metabolic Syndrome1758-59962023-04-011511910.1186/s13098-023-01030-zCumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetesMin-Kyung Lee0Jae-Hyuk Lee1Seo Young Sohn2Jiyeon Ahn3Oak-Kee Hong4Mee-Kyoung Kim5Ki-Hyun Baek6Ki-Ho Song7Kyungdo Han8Hyuk-Sang Kwon9Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Background Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. Methods Data of 1,376,540 participants aged 20–39 years without a history of type 2 diabetes and who underwent four annual health check-ups were collected. In this large-scale prospective cohort study, we evaluated the incidence rates and hazard ratios (HRs) of diabetes according to cumulative frequencies of metabolic syndrome over 4 years of consecutive annual health check-ups (burden score 0–4). Subgroup analyses were performed by sex and age. Results During 5.18 years of follow-up, 18,155 young adults developed type 2 diabetes. The incidence of type 2 diabetes increased with burden score (P < 0.0001). The multivariable-adjusted HRs for type 2 diabetes were 4.757, 10.511, 18.288, and 31.749 in participants with a burden score of 1 to 4, respectively, compared to those with 0. In subgroup analyses, the risk of incident diabetes was greater in women than men and in the 20–29 years age group than the 30–39 years age group. The HRs were 47.473 in women and 27.852 in men with four burden scores. Conclusion The risk of type 2 diabetes significantly increased with an increase in the cumulative burden of metabolic syndrome in young adults. Additionally, the association between cumulative burden and diabetes risk was stronger in women and the 20s age group.https://doi.org/10.1186/s13098-023-01030-zCumulative burdenMetabolic syndromeType 2 diabetesYoung adults |
| spellingShingle | Min-Kyung Lee Jae-Hyuk Lee Seo Young Sohn Jiyeon Ahn Oak-Kee Hong Mee-Kyoung Kim Ki-Hyun Baek Ki-Ho Song Kyungdo Han Hyuk-Sang Kwon Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes Diabetology & Metabolic Syndrome Cumulative burden Metabolic syndrome Type 2 diabetes Young adults |
| title | Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes |
| title_full | Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes |
| title_fullStr | Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes |
| title_full_unstemmed | Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes |
| title_short | Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes |
| title_sort | cumulative exposure to metabolic syndrome in a national population based cohort of young adults and sex specific risk for type 2 diabetes |
| topic | Cumulative burden Metabolic syndrome Type 2 diabetes Young adults |
| url | https://doi.org/10.1186/s13098-023-01030-z |
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