Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia

Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia

Objectives: To analyze the frequency of βS-globin haplotypes and alpha-thalassemia, and their influence on clinical manifestations and the hematological profile of children with sickle cell anemia. Method: The frequency of βS-globin haplotypes and alpha-thalassemia and any association with clinical...

Full description

Bibliographic Details
Main Authors:	Roberta Faria Camilo-Araújo, Olga Maria Silverio Amancio, Maria Stella Figueiredo, Ana Carolina Cabanãs-Pedro, Josefina Aparecida Pellegrini Braga
Format:	Article
Language:	English
Published:	Elsevier 2014-10-01
Series:	Revista Brasileira de Hematologia e Hemoterapia
Subjects:	Anemia, Sickle Cell Alpha-thalassemia Beta-globins Haplotypes Child
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000500334&lng=en&tlng=en

Similar Items

Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis
by: Zefarina Zulkafli, et al.
Published: (2022-01-01)

Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
by: Cynthia Hatsue Kitayama Cabral, et al.
Published: (2011-01-01)

Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
by: Cynthia Hatsue Kitayama Cabral, et al.
Published: (2011-01-01)

Frequency and origin of haplotypes associated with the beta-globin gene cluster in individuals with trait and sickle cell anemia in the Atlantic and Pacific coastal regions of Colombia
by: Cristian Fong, et al.
Published: (2013-01-01)

Clinical, hematological, and molecular characterization of sickle cell anemia pediatric patients from two different cities in Brazil Caracterização clínica, hematológica e molecular de crianças portadoras da anemia falciforme em duas diferentes cidades do Brasil
by: Isa Menezes Lyra, et al.
Published: (2005-08-01)

Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
by: Nancy Moreno, et al.
Published: (2002-01-01)

Genetic determinants and stroke in children with sickle cell disease
by: Daniela O.W. Rodrigues, et al.
Published: (2016-11-01)

Beta globin gene cluster haplotypes of the beta thalassemia mutations observed in the Denizli province of Turkey
by: Anzel Bahadır, et al.
Published: (2009-09-01)

Análise dos haplótipos da anemia falciforme em Fortaleza revela as origens étnicas da população cearense Analysis of sickle cell anemia haplotypes in Fortaleza reveals the ethnic origins of Ceará state population
by: Lilianne Brito da Silva, et al.
Published: (2009-04-01)

Alpha‐globin gene triplication and its effect in beta‐thalassemia carrier, sickle cell trait, and healthy individual
by: Mohammad Hamid, et al.
Published: (2021-08-01)

Kidney dysfunction and beta S-haplotypes in patients with sickle cell disease
by: Lilianne Brito da Silva Rocha, et al.
Published: (2013-06-01)

Haplotype Analysis in Carriers of β-Globin Gene Mutation Facil-itates Genetic Counseling in β-Thalassemia: A Cross-Sectional Study in Kerman Province, Iran
by: Nasrollah SALEH-GOHARI, et al.
Published: (2020-04-01)

Análise dos haplótipos do gene da betaS-globina no Ceará Analysis of betaS-globin gene haplotypes in Ceará, Brazil
by: Gentil Claudino de Galiza Neto, et al.
Published: (2005-10-01)

The frequency of βS-globin haplotypes in the state of Paraná, Brazil, and clinical manifestations of sickle cell anemia
by: Alexandra M. Watanabe, et al.

A model for gene therapy : gene replacement in the treatment of sickle cell anemia and B thalassemia /
by: 234771 Merkeley, Ward
Published: (2005)

Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional study
by: Noor Taha Yaseen, et al.
Published: (2020-01-01)

Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I
by: Maria Francesca Manchinu, et al.
Published: (2020-05-01)

Baby Ballou: A Case of an Abnormal Newborn Screen
by: Amy Holthouser
Published: (2008-05-01)

Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia
by: Marília Rocha Laurentino, et al.
Published: (2014-04-01)

Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
by: Rayan Bou-Fakhredin, et al.
Published: (2022-06-01)

Sickle Cell Trait and Sickle Cell Disease: A Case Study
by: Shoumita Dasgupta
Published: (2009-09-01)

ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
by: M.S. Gonçalves, et al.
Published: (2003-10-01)

Cutaneous manifestation of sickle cell disease
by: Rashmi Patnayak, et al.
Published: (2021-01-01)

Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection
by: Raffaella Colombatti, et al.
Published: (2023-08-01)

beta-thalassemia intermedia in a Brazilian patient with - 101(C > T) and codon 39 (C > T) mutations
by: Sylvia Morais de Sousa, et al.

Identification of Sickle Cell Anemia Using Deep Neural Networks
by: Sagar Yeruva, et al.
Published: (2021-04-01)

Prevalence of hemoglobinopathies in premarriage individuals referred to Babolsar, Iran (2006-09)
by: Valizadeh F (MD), et al.
Published: (2012-03-01)

Comparison of MLPA Method for Detection of Known and Unknown Deletions in Beta Globin Gene Cluster with Old Methods (REAL-TIME, RFLP, Gap-PCR)
by: R. Alimohammadi, et al.
Published: (2009-02-01)

Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil
by: Elisângela Vitória Adorno, et al.
Published: (2008-01-01)

Investigating alpha-globin structural variants: a retrospective review of 135,000 Brazilian individuals
by: Elza Miyuki Kimura, et al.
Published: (2015-04-01)

Diversidade clínica e laboratorial no haplótipo bantu da anemia falciforme Clinical and laboratorial diversity in the bantu haplotype of sickle cell anemia
by: Paulo J. M. S. Costa, et al.
Published: (2006-03-01)

Prevalence and Genetic Analysis of α- and β-Thalassemia and Sickle Cell Anemia in Southwest Iran
by: Forozan H. Nezhad, et al.
Published: (2018-12-01)

Fetal Haemoglobin and β-globin Gene Cluster Haplotypes among Sickle Cell Patients in Chhattisgarh
by: Sanjana Bhagat, et al.
Published: (2013-02-01)

Gilbert syndrome in patients with inherited hemolytic anemia modifies the clinical phenotype
by: Anika Agrawal, et al.
Published: (2024-06-01)

Molecular Analysis of β-Globin Mutations Among β-Thalassemia Patients in Hamadan
by: Fatemeh Ramezani, et al.
Published: (2021-06-01)

Thalassemia, a human blood disorder
by: F. Shafique, et al.
Published: (2021-09-01)

Evaluation of common mutations in β-thalassemia patients in Iranian populations using SNaPshot method
by: Mehrzad S, et al.
Published: (2020-07-01)

Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
by: Milena Magalhães Aleluia, et al.
Published: (2017-04-01)

Frequency and spectrum of hemoglobinopathy mutations in a Uruguayan pediatric population
by: Julio Da Luz, et al.
Published: (2013-01-01)

Sickle cell disease: acute clinical manifestations in early childhood and molecular characteristics in a group of children in Rio de Janeiro Manifestações clínicas agudas na primeira e segunda infâncias e características moleculares da doença falciforme em um grupo de crianças do Rio de Janeiro
by: Isaac Lima da Silva Filho, et al.
Published: (2012-01-01)