Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is an aggressive and challenging disease to treat. Due to the lack of effective early diagnosis and therapy for the illness, it is crucial to identify novel biomarkers that can predict tumor behavior in HCC. In such cases, family with sequence similarity 210 member B (...
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1232 |
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| author | Yuanqin Zhou Xianzhu Pan Yakun Liu Xiaofei Li Keqiong Lin Jicheng Zhu Li Zhan Chen Kan Hong Zheng |
| author_facet | Yuanqin Zhou Xianzhu Pan Yakun Liu Xiaofei Li Keqiong Lin Jicheng Zhu Li Zhan Chen Kan Hong Zheng |
| author_sort | Yuanqin Zhou |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is an aggressive and challenging disease to treat. Due to the lack of effective early diagnosis and therapy for the illness, it is crucial to identify novel biomarkers that can predict tumor behavior in HCC. In such cases, family with sequence similarity 210 member B (FAM210B) is abundant in various human tissues, but its regulatory mechanisms and role in various tissues remain unclear. In this study, we analyzed the expression pattern of FAM210B in HCC using public gene expression databases and clinical tissue samples. Our results confirmed that FAM210B was dysregulated in both HCC cell lines and HCC paraffin section samples. FAM210B depletion significantly increased the capacity of cells to grow, migrate, and invade in vitro, while overexpression of FAM210B suppressed tumor growth in a xenograft tumor model. Furthermore, we identified FAM210B’s involvement in MAPK signaling and p-AKT signaling pathways, both of which are known oncogenic signaling pathways. In summary, our study provides a rational basis for the further investigation of FAM210B as a valuable biological marker for diagnosing and predicting the prognosis of HCC patients. |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:12:03Z |
| publishDate | 2023-04-01 |
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| series | Biomedicines |
| spelling | doaj.art-7905f6970f64469aabcef456234d8a642023-11-17T18:28:23ZengMDPI AGBiomedicines2227-90592023-04-01114123210.3390/biomedicines11041232Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular CarcinomaYuanqin Zhou0Xianzhu Pan1Yakun Liu2Xiaofei Li3Keqiong Lin4Jicheng Zhu5Li Zhan6Chen Kan7Hong Zheng8Department of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathology and Pathophysiology, School of Basic Medicine, Anhui Medical College, Hefei 230601, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaHepatocellular carcinoma (HCC) is an aggressive and challenging disease to treat. Due to the lack of effective early diagnosis and therapy for the illness, it is crucial to identify novel biomarkers that can predict tumor behavior in HCC. In such cases, family with sequence similarity 210 member B (FAM210B) is abundant in various human tissues, but its regulatory mechanisms and role in various tissues remain unclear. In this study, we analyzed the expression pattern of FAM210B in HCC using public gene expression databases and clinical tissue samples. Our results confirmed that FAM210B was dysregulated in both HCC cell lines and HCC paraffin section samples. FAM210B depletion significantly increased the capacity of cells to grow, migrate, and invade in vitro, while overexpression of FAM210B suppressed tumor growth in a xenograft tumor model. Furthermore, we identified FAM210B’s involvement in MAPK signaling and p-AKT signaling pathways, both of which are known oncogenic signaling pathways. In summary, our study provides a rational basis for the further investigation of FAM210B as a valuable biological marker for diagnosing and predicting the prognosis of HCC patients.https://www.mdpi.com/2227-9059/11/4/1232hepatocellular carcinomamitochondrial membrane proteinFAM210BMAPK signalingPI3K/AKT signalingmetastasis |
| spellingShingle | Yuanqin Zhou Xianzhu Pan Yakun Liu Xiaofei Li Keqiong Lin Jicheng Zhu Li Zhan Chen Kan Hong Zheng Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma Biomedicines hepatocellular carcinoma mitochondrial membrane protein FAM210B MAPK signaling PI3K/AKT signaling metastasis |
| title | Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma |
| title_full | Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma |
| title_fullStr | Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma |
| title_full_unstemmed | Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma |
| title_short | Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma |
| title_sort | loss of the novel mitochondrial membrane protein fam210b is associated with hepatocellular carcinoma |
| topic | hepatocellular carcinoma mitochondrial membrane protein FAM210B MAPK signaling PI3K/AKT signaling metastasis |
| url | https://www.mdpi.com/2227-9059/11/4/1232 |
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