Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A–GATA3–STAT3 Circuit

Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A–GATA3–STAT3 Circuit

Bladder cancer stem cells (BCSCs) have the abilities of self-renewal, differentiation, and metastasis; confer drug resistance; and exhibit high tumorigenicity. We previously identified that the KMT1A–GATA3–STAT3 axis drives the self-renewal of BCSCs. However, the therapeutic effect of targeting KMT1...

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Bibliographic Details
Main Authors: Zhao Yang, Haifeng Wang, Nan Zhang, Tianying Xing, Wei Zhang, Guoqing Wang, Chong Li, Changyuan Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
bladder cancer
bladder cancer stem cells
KMT1A
chaetocin
target therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00424/full

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