Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report
Lung cancer is one of the most common and lethal cancers worldwide. Numerous medications targeting specific molecular alterations in non-small cell lung cancer have been introduced in the last decade and have revolutionized the clinical management of the disease. Their use has brought to a parallel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1874 |
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| author | Giovanni M. Fadda Renato Lobrano Milena Casula Marina Pisano Antonio Pazzola Antonio Cossu Giuseppe Palmieri Panagiotis Paliogiannis |
| author_facet | Giovanni M. Fadda Renato Lobrano Milena Casula Marina Pisano Antonio Pazzola Antonio Cossu Giuseppe Palmieri Panagiotis Paliogiannis |
| author_sort | Giovanni M. Fadda |
| collection | DOAJ |
| description | Lung cancer is one of the most common and lethal cancers worldwide. Numerous medications targeting specific molecular alterations in non-small cell lung cancer have been introduced in the last decade and have revolutionized the clinical management of the disease. Their use has brought to a parallel evolution of molecular testing techniques to identify alterations in druggable molecular targets within the genetic material of the tumors. To perform molecular testing, biopsy or surgery tissue specimens are needed, which in addition allow the histological characterization of the tumors. Unfortunately, in real-life practice not all the patients are suitable for biopsy or surgery procedures. The use of liquid biopsy for blood extracted tumoral DNA analysis is a promising approach in unbiopsied cases, but it is also weighted by several methodological and technical limitations. We report here a case of histologically undiagnosed lung cancer managed with a liquid biopsy and subsequently with anti-EGFR treatment. Our report highlights that the use of liquid biopsy molecular testing in specific clinical situations can offer treatment opportunities for fragile patients affected by lung cancer. |
| first_indexed | 2024-03-09T18:55:48Z |
| format | Article |
| id | doaj.art-790b92a242424c258bd203ce69b8c12d |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:55:48Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-790b92a242424c258bd203ce69b8c12d2023-11-24T05:26:35ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011211187410.3390/jpm12111874Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case ReportGiovanni M. Fadda0Renato Lobrano1Milena Casula2Marina Pisano3Antonio Pazzola4Antonio Cossu5Giuseppe Palmieri6Panagiotis Paliogiannis7Medical Oncology Unit, University Hospital (AOU) of Sassari, Via Enrico De Nicola 1, 07100 Sassari, ItalyAnatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyInstitute of Genetic and Biomolecular Research, National Research Council (CNR), Traversa La Crucca 3, 07100 Sassari, ItalyInstitute of Genetic and Biomolecular Research, National Research Council (CNR), Traversa La Crucca 3, 07100 Sassari, ItalyMedical Oncology Unit, University Hospital (AOU) of Sassari, Via Enrico De Nicola 1, 07100 Sassari, ItalyAnatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyInstitute of Genetic and Biomolecular Research, National Research Council (CNR), Traversa La Crucca 3, 07100 Sassari, ItalyAnatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyLung cancer is one of the most common and lethal cancers worldwide. Numerous medications targeting specific molecular alterations in non-small cell lung cancer have been introduced in the last decade and have revolutionized the clinical management of the disease. Their use has brought to a parallel evolution of molecular testing techniques to identify alterations in druggable molecular targets within the genetic material of the tumors. To perform molecular testing, biopsy or surgery tissue specimens are needed, which in addition allow the histological characterization of the tumors. Unfortunately, in real-life practice not all the patients are suitable for biopsy or surgery procedures. The use of liquid biopsy for blood extracted tumoral DNA analysis is a promising approach in unbiopsied cases, but it is also weighted by several methodological and technical limitations. We report here a case of histologically undiagnosed lung cancer managed with a liquid biopsy and subsequently with anti-EGFR treatment. Our report highlights that the use of liquid biopsy molecular testing in specific clinical situations can offer treatment opportunities for fragile patients affected by lung cancer.https://www.mdpi.com/2075-4426/12/11/1874lung canceradenocarcinomatargeted therapyEGFRliquid biopsy |
| spellingShingle | Giovanni M. Fadda Renato Lobrano Milena Casula Marina Pisano Antonio Pazzola Antonio Cossu Giuseppe Palmieri Panagiotis Paliogiannis Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report Journal of Personalized Medicine lung cancer adenocarcinoma targeted therapy EGFR liquid biopsy |
| title | Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report |
| title_full | Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report |
| title_fullStr | Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report |
| title_full_unstemmed | Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report |
| title_short | Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report |
| title_sort | liquid biopsy in the oncological management of a histologically undiagnosed lung carcinoma a case report |
| topic | lung cancer adenocarcinoma targeted therapy EGFR liquid biopsy |
| url | https://www.mdpi.com/2075-4426/12/11/1874 |
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