Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment
Traditional Radiation Therapy (RT) predominantly comprises a targeted therapeutic strategy focused on improving localised tumour control and achieving a cure while minimising the occurrence of adverse side effects. It could be feasible to take advantage of the better dose distribution by enabling la...
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JCDR Research and Publications Private Limited
2024-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18992/68692_CE[Ra1]_F(SS)_QC(SD_RDW_IS)_PF1(VD_DK)_PFA(VD_KM)_PN(KM).pdf |
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| author | Tamalika Chakraborty Ammar A Razzak Mahmood Jyoti Kataria Amutha Chellathurai Vanitha Innocent Rani Muthu Prasanna |
| author_facet | Tamalika Chakraborty Ammar A Razzak Mahmood Jyoti Kataria Amutha Chellathurai Vanitha Innocent Rani Muthu Prasanna |
| author_sort | Tamalika Chakraborty |
| collection | DOAJ |
| description | Traditional Radiation Therapy (RT) predominantly comprises a targeted therapeutic strategy focused on improving localised tumour control and achieving a cure while minimising the occurrence of adverse side effects. It could be feasible to take advantage of the better dose distribution by enabling larger RT dosages to the malignancy while preventing a rise in the toxicity of RT-induced healthy tissue, or by reducing adverse reactions to manageable levels. Poor local disease control and important dose-limiting normal tissue, which prevent safe dosage increase with conventional photon RT, have been the key justifications for RT. Proton treatment, on the other hand, delivers therapeutic protons or positive particles using proton beams. The potential advantage of
protons’ physical properties allows for more localised RT delivery. By increasing the dosage to equitoxic levels, it is also possible to take advantage of the potential improvement in normal tissue sparing to support local tumour management and, ideally, longevity. Proton treatment preserves more important structures than photon therapy because of its unique physics. Thus, there is a need for wide usage of Proton Therapy (PT) for successive cancer treatment. The present review focuses on PT based on tumour site, clinical studies, biological barriers, instrumentation of PT, significance, and limitations. |
| first_indexed | 2024-03-08T11:38:20Z |
| format | Article |
| id | doaj.art-790ccab6bd3c4990880e8be4638f21e4 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-08T11:38:20Z |
| publishDate | 2024-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-790ccab6bd3c4990880e8be4638f21e42024-01-25T11:04:45ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-02-011802010710.7860/JCDR/2024/68692.18992Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer TreatmentTamalika Chakraborty0Ammar A Razzak Mahmood1Jyoti Kataria2Amutha Chellathurai3Vanitha Innocent Rani4Muthu Prasanna5Assistant Professor, Department of Life Science, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad. Bab-Al-Mouadam, Baghdad, Iraq.Assistant Professor, Department of Physiotherapy, Banarsidas Chandiwala Institute of Physiotherapy, New Delhi, India.Lecturer, Department of Nursing-paediatric, King Khalid University, Abha, Saudi Arabia.Assistant Professor, Department of Nursing Psychiatric, King Khalid University, Abha, Saudi Arabia.Professor, Department of Pharmaceutical Biotechnology, Surya School of Pharmacy, Villupuram, Tamil Nadu, India.Traditional Radiation Therapy (RT) predominantly comprises a targeted therapeutic strategy focused on improving localised tumour control and achieving a cure while minimising the occurrence of adverse side effects. It could be feasible to take advantage of the better dose distribution by enabling larger RT dosages to the malignancy while preventing a rise in the toxicity of RT-induced healthy tissue, or by reducing adverse reactions to manageable levels. Poor local disease control and important dose-limiting normal tissue, which prevent safe dosage increase with conventional photon RT, have been the key justifications for RT. Proton treatment, on the other hand, delivers therapeutic protons or positive particles using proton beams. The potential advantage of protons’ physical properties allows for more localised RT delivery. By increasing the dosage to equitoxic levels, it is also possible to take advantage of the potential improvement in normal tissue sparing to support local tumour management and, ideally, longevity. Proton treatment preserves more important structures than photon therapy because of its unique physics. Thus, there is a need for wide usage of Proton Therapy (PT) for successive cancer treatment. The present review focuses on PT based on tumour site, clinical studies, biological barriers, instrumentation of PT, significance, and limitations.https://www.jcdr.net/articles/PDF/18992/68692_CE[Ra1]_F(SS)_QC(SD_RDW_IS)_PF1(VD_DK)_PFA(VD_KM)_PN(KM).pdfproton beamsproton treatmentradiation therapytissue toxicity |
| spellingShingle | Tamalika Chakraborty Ammar A Razzak Mahmood Jyoti Kataria Amutha Chellathurai Vanitha Innocent Rani Muthu Prasanna Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment Journal of Clinical and Diagnostic Research proton beams proton treatment radiation therapy tissue toxicity |
| title | Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment |
| title_full | Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment |
| title_fullStr | Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment |
| title_full_unstemmed | Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment |
| title_short | Current Perspectives on Proton Therapy: Techniques Shaping the Future of Cancer Treatment |
| title_sort | current perspectives on proton therapy techniques shaping the future of cancer treatment |
| topic | proton beams proton treatment radiation therapy tissue toxicity |
| url | https://www.jcdr.net/articles/PDF/18992/68692_CE[Ra1]_F(SS)_QC(SD_RDW_IS)_PF1(VD_DK)_PFA(VD_KM)_PN(KM).pdf |
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