The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/2/807 |
| _version_ | 1797493307587166208 |
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| author | Charlotte Delrue Reinhart Speeckaert Joris R. Delanghe Marijn M. Speeckaert |
| author_facet | Charlotte Delrue Reinhart Speeckaert Joris R. Delanghe Marijn M. Speeckaert |
| author_sort | Charlotte Delrue |
| collection | DOAJ |
| description | According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach. |
| first_indexed | 2024-03-10T01:18:09Z |
| format | Article |
| id | doaj.art-790e120a25b24d90903afee7accbd406 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:18:09Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-790e120a25b24d90903afee7accbd4062023-11-23T14:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123280710.3390/ijms23020807The Role of Vitamin D in Diabetic Nephropathy: A Translational ApproachCharlotte Delrue0Reinhart Speeckaert1Joris R. Delanghe2Marijn M. Speeckaert3Department of Nephrology, Ghent University Hospital, 9000 Ghent, BelgiumDepartment of Dermatology, Ghent University Hospital, 9000 Ghent, BelgiumDepartment of Diagnostic Sciences, Ghent University, 9000 Ghent, BelgiumDepartment of Nephrology, Ghent University Hospital, 9000 Ghent, BelgiumAccording to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.https://www.mdpi.com/1422-0067/23/2/807diabetes mellitusdiabetic nephropathyvitamin D |
| spellingShingle | Charlotte Delrue Reinhart Speeckaert Joris R. Delanghe Marijn M. Speeckaert The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach International Journal of Molecular Sciences diabetes mellitus diabetic nephropathy vitamin D |
| title | The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach |
| title_full | The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach |
| title_fullStr | The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach |
| title_full_unstemmed | The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach |
| title_short | The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach |
| title_sort | role of vitamin d in diabetic nephropathy a translational approach |
| topic | diabetes mellitus diabetic nephropathy vitamin D |
| url | https://www.mdpi.com/1422-0067/23/2/807 |
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