Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability
p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease. Inducible deletion of the p35 gene in adult mice results in profound deficits in hippocampal-depen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2018.00138/full |
| _version_ | 1818234152525234176 |
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| author | Eriko Kamiki Eriko Kamiki Roman Boehringer Denis Polygalov Toshio Ohshima Thomas J. McHugh |
| author_facet | Eriko Kamiki Eriko Kamiki Roman Boehringer Denis Polygalov Toshio Ohshima Thomas J. McHugh |
| author_sort | Eriko Kamiki |
| collection | DOAJ |
| description | p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease. Inducible deletion of the p35 gene in adult mice results in profound deficits in hippocampal-dependent spatial learning and synaptic physiology, however the impact of the loss of p35 function on hippocampal in vivo physiology and spatial coding remains unknown. Here, we recorded CA1 pyramidal cell activity in freely behaving p35 cKO and control mice and found that place cells in the mutant mice have elevated firing rates and impaired spatial coding, accompanied by changes in the temporal organization of spiking both during exploration and rest. These data shed light on the role of p35 in maintaining cellular and network excitability and provide a physiological correlate of the spatial learning deficits in these mice. |
| first_indexed | 2024-12-12T11:33:32Z |
| format | Article |
| id | doaj.art-790f5d3d91ab435b8474ecb58a73fbb8 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T11:33:32Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-790f5d3d91ab435b8474ecb58a73fbb82022-12-22T00:25:44ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-05-011210.3389/fncel.2018.00138324488Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal ExcitabilityEriko Kamiki0Eriko Kamiki1Roman Boehringer2Denis Polygalov3Toshio Ohshima4Thomas J. McHugh5Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, JapanLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wako-shi, JapanLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wako-shi, JapanLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wako-shi, JapanLaboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Waseda University, Tokyo, JapanLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wako-shi, Japanp35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease. Inducible deletion of the p35 gene in adult mice results in profound deficits in hippocampal-dependent spatial learning and synaptic physiology, however the impact of the loss of p35 function on hippocampal in vivo physiology and spatial coding remains unknown. Here, we recorded CA1 pyramidal cell activity in freely behaving p35 cKO and control mice and found that place cells in the mutant mice have elevated firing rates and impaired spatial coding, accompanied by changes in the temporal organization of spiking both during exploration and rest. These data shed light on the role of p35 in maintaining cellular and network excitability and provide a physiological correlate of the spatial learning deficits in these mice.http://journal.frontiersin.org/article/10.3389/fncel.2018.00138/fullcyclin-dependent kinase 5p35hippocampusCA1spatial codingneuronal excitability |
| spellingShingle | Eriko Kamiki Eriko Kamiki Roman Boehringer Denis Polygalov Toshio Ohshima Thomas J. McHugh Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability Frontiers in Cellular Neuroscience cyclin-dependent kinase 5 p35 hippocampus CA1 spatial coding neuronal excitability |
| title | Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability |
| title_full | Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability |
| title_fullStr | Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability |
| title_full_unstemmed | Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability |
| title_short | Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability |
| title_sort | inducible knockout of the cyclin dependent kinase 5 activator p35 alters hippocampal spatial coding and neuronal excitability |
| topic | cyclin-dependent kinase 5 p35 hippocampus CA1 spatial coding neuronal excitability |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2018.00138/full |
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