Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability

Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability

p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease. Inducible deletion of the p35 gene in adult mice results in profound deficits in hippocampal-depen...

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Bibliographic Details
Main Authors: Eriko Kamiki, Roman Boehringer, Denis Polygalov, Toshio Ohshima, Thomas J. McHugh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cyclin-dependent kinase 5
p35
hippocampus
CA1
spatial coding
neuronal excitability
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00138/full

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