Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin
Hypervirulent Klebsiella pneumoniae (hvKP) with a high mucus phenotype, can cause liver abscess and extrahepatic invasive infection. The morbidity of hvKP infections has increased recently. Here we describe a case report of septicemia caused by hvKP due to the term septic arthritis of right knee joi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250921002328 |
| _version_ | 1819319521863794688 |
|---|---|
| author | Yong-Chun Lin Xi Cao Yun-Chao Mo Cai-Peng Xie Yong-Fang Zhang Na Li Hua-Ling Chen |
| author_facet | Yong-Chun Lin Xi Cao Yun-Chao Mo Cai-Peng Xie Yong-Fang Zhang Na Li Hua-Ling Chen |
| author_sort | Yong-Chun Lin |
| collection | DOAJ |
| description | Hypervirulent Klebsiella pneumoniae (hvKP) with a high mucus phenotype, can cause liver abscess and extrahepatic invasive infection. The morbidity of hvKP infections has increased recently. Here we describe a case report of septicemia caused by hvKP due to the term septic arthritis of right knee joint in a 29-year-old male. The patient was persistent fever with a peak temperature at 40.6 °C. However, based on the drug sensitivity, the treatment failed frequently. The patient did not improve clinically on susceptible monotherapy antimicrobial. Combination therapy with meropenem and rifampicin (RFP) lead to clinical improvement and discharge. |
| first_indexed | 2024-12-24T11:04:58Z |
| format | Article |
| id | doaj.art-7910cf448dbe4809803ca4a4f9237950 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-24T11:04:58Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-7910cf448dbe4809803ca4a4f92379502022-12-21T16:58:38ZengElsevierIDCases2214-25092021-01-0126e01276Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicinYong-Chun Lin0Xi Cao1Yun-Chao Mo2Cai-Peng Xie3Yong-Fang Zhang4Na Li5Hua-Ling Chen6Department of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaCorresponding author.; Department of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, ChinaHypervirulent Klebsiella pneumoniae (hvKP) with a high mucus phenotype, can cause liver abscess and extrahepatic invasive infection. The morbidity of hvKP infections has increased recently. Here we describe a case report of septicemia caused by hvKP due to the term septic arthritis of right knee joint in a 29-year-old male. The patient was persistent fever with a peak temperature at 40.6 °C. However, based on the drug sensitivity, the treatment failed frequently. The patient did not improve clinically on susceptible monotherapy antimicrobial. Combination therapy with meropenem and rifampicin (RFP) lead to clinical improvement and discharge.http://www.sciencedirect.com/science/article/pii/S2214250921002328Hypervirulent Klebsiella pneumoniaeBacteremiaLiver abscessCarbapenemsRifampicin |
| spellingShingle | Yong-Chun Lin Xi Cao Yun-Chao Mo Cai-Peng Xie Yong-Fang Zhang Na Li Hua-Ling Chen Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin IDCases Hypervirulent Klebsiella pneumoniae Bacteremia Liver abscess Carbapenems Rifampicin |
| title | Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| title_full | Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| title_fullStr | Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| title_full_unstemmed | Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| title_short | Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| title_sort | successful treatment of hypervirulent klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin |
| topic | Hypervirulent Klebsiella pneumoniae Bacteremia Liver abscess Carbapenems Rifampicin |
| url | http://www.sciencedirect.com/science/article/pii/S2214250921002328 |
| work_keys_str_mv | AT yongchunlin successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT xicao successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT yunchaomo successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT caipengxie successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT yongfangzhang successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT nali successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin AT hualingchen successfultreatmentofhypervirulentklebsiellapneumoniaebacteremiawithcombinationcarbapenemandrifampicin |