A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
The poultry red mite (PRM), <i>Dermanyssus gallinae</i>, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/7/4/190 |
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| author | José Francisco Lima-Barbero Marinela Contreras Lourdes Mateos-Hernández Francisco Manuel Mata-Lorenzo Roxana Triguero-Ocaña Olivier Sparagano Robert D. Finn Christina Strube Daniel R.G. Price Francesca Nunn Kathryn Bartley Ursula Höfle Mariana Boadella Alasdair J. Nisbet José de la Fuente Margarita Villar |
| author_facet | José Francisco Lima-Barbero Marinela Contreras Lourdes Mateos-Hernández Francisco Manuel Mata-Lorenzo Roxana Triguero-Ocaña Olivier Sparagano Robert D. Finn Christina Strube Daniel R.G. Price Francesca Nunn Kathryn Bartley Ursula Höfle Mariana Boadella Alasdair J. Nisbet José de la Fuente Margarita Villar |
| author_sort | José Francisco Lima-Barbero |
| collection | DOAJ |
| description | The poultry red mite (PRM), <i>Dermanyssus gallinae</i>, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. <i>Rhipicephalus</i> <i>microplus</i> Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control. |
| first_indexed | 2024-04-12T19:25:05Z |
| format | Article |
| id | doaj.art-79114402d5a848b780b8825ead0ffee4 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-12T19:25:05Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-79114402d5a848b780b8825ead0ffee42022-12-22T03:19:30ZengMDPI AGVaccines2076-393X2019-11-017419010.3390/vaccines7040190vaccines7040190A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite InfestationsJosé Francisco Lima-Barbero0Marinela Contreras1Lourdes Mateos-Hernández2Francisco Manuel Mata-Lorenzo3Roxana Triguero-Ocaña4Olivier Sparagano5Robert D. Finn6Christina Strube7Daniel R.G. Price8Francesca Nunn9Kathryn Bartley10Ursula Höfle11Mariana Boadella12Alasdair J. Nisbet13José de la Fuente14Margarita Villar15SaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainUMR BIPAR, INRA, Ecole Nationale Vétérinaire d´Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, FranceSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainDepartment of Infectious Diseases and Public Health, City University of Hong Kong, Kowloon, Hong Kong SARDepartment of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UKInstitute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hannover, GermanyMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UKMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UKMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UKSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainSabiotec, S.A. Ed. Polivalente UCLM. Camino de Moledores. 13005. Ciudad Real, SpainMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UKSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainSaBio. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071, Ciudad Real, SpainThe poultry red mite (PRM), <i>Dermanyssus gallinae</i>, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. <i>Rhipicephalus</i> <i>microplus</i> Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.https://www.mdpi.com/2076-393X/7/4/190dermanyssuspoultry red miteproteomicsvaccinevaccinologycontrolprotective antigens |
| spellingShingle | José Francisco Lima-Barbero Marinela Contreras Lourdes Mateos-Hernández Francisco Manuel Mata-Lorenzo Roxana Triguero-Ocaña Olivier Sparagano Robert D. Finn Christina Strube Daniel R.G. Price Francesca Nunn Kathryn Bartley Ursula Höfle Mariana Boadella Alasdair J. Nisbet José de la Fuente Margarita Villar A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations Vaccines dermanyssus poultry red mite proteomics vaccine vaccinology control protective antigens |
| title | A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| title_full | A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| title_fullStr | A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| title_full_unstemmed | A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| title_short | A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| title_sort | vaccinology approach to the identification and characterization of i dermanyssus gallinae i candidate protective antigens for the control of poultry red mite infestations |
| topic | dermanyssus poultry red mite proteomics vaccine vaccinology control protective antigens |
| url | https://www.mdpi.com/2076-393X/7/4/190 |
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