Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score
Coronary artery disease (CAD) continues to be a foremost contributor to global mortality, and the quest for modifiable risk factors could improve prophylactic strategies. Recent studies suggest a significant role of zinc (Zn) and copper (Cu) deficiency in atheromatous plaque formation. Furthermore,...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/11/1407 |
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| author | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Ewa Czestkowska Joanna Beck Beata Jaczewska Elżbieta Zgnilec Andrzej Osiecki Mirosław Kwaśny Marek J. Dąbrowski Wacław Kochman |
| author_facet | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Ewa Czestkowska Joanna Beck Beata Jaczewska Elżbieta Zgnilec Andrzej Osiecki Mirosław Kwaśny Marek J. Dąbrowski Wacław Kochman |
| author_sort | Ewelina A. Dziedzic |
| collection | DOAJ |
| description | Coronary artery disease (CAD) continues to be a foremost contributor to global mortality, and the quest for modifiable risk factors could improve prophylactic strategies. Recent studies suggest a significant role of zinc (Zn) and copper (Cu) deficiency in atheromatous plaque formation. Furthermore, hair was previously described as a valuable source of information on elemental burden during the 6–8 week period before sampling. The aim of this study was to investigate the possibility of correlation between the extent of CAD evaluated with the SYNergy Between PCI With TAXUS and the Cardiac Surgery (SYNTAX) score with Cu and Zn content in hair samples, as well as with the Cu/Zn ratio in a cohort of 130 patients. Our findings describe a statistically significant inverse correlation between Cu content and the Cu/Zn ratio in hair samples and the extent of CAD. In contrast, no significant correlation was found between Zn content and the extent of CAD. Considering the scarcity of existing data on the subject, the analysis of hair samples could yield a novel insight into elemental deficiencies and their potential influence on CAD extent. |
| first_indexed | 2024-03-09T17:00:40Z |
| format | Article |
| id | doaj.art-791318f291914c1ea22ec004b6f286b0 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T17:00:40Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-791318f291914c1ea22ec004b6f286b02023-11-24T14:30:17ZengMDPI AGBiology2079-77372023-11-011211140710.3390/biology12111407Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX ScoreEwelina A. Dziedzic0Jakub S. Gąsior1Agnieszka Tuzimek2Ewa Czestkowska3Joanna Beck4Beata Jaczewska5Elżbieta Zgnilec6Andrzej Osiecki7Mirosław Kwaśny8Marek J. Dąbrowski9Wacław Kochman10Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandCardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandCardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandNencki Institute of Experimental Biology, Polish Academy of Sciences, 00-901 Warsaw, PolandMedical Faculty, Lazarski University, 02-662 Warsaw, PolandMilitary Institute of Aviation Medicine, 01-755 Warsaw, PolandCardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandInstitute of Optoelectronics, Military University of Technology, 00-908 Warsaw, PolandDepartment of Cardiology, Bielanski Hospital, 01-809 Warsaw, PolandCardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandCoronary artery disease (CAD) continues to be a foremost contributor to global mortality, and the quest for modifiable risk factors could improve prophylactic strategies. Recent studies suggest a significant role of zinc (Zn) and copper (Cu) deficiency in atheromatous plaque formation. Furthermore, hair was previously described as a valuable source of information on elemental burden during the 6–8 week period before sampling. The aim of this study was to investigate the possibility of correlation between the extent of CAD evaluated with the SYNergy Between PCI With TAXUS and the Cardiac Surgery (SYNTAX) score with Cu and Zn content in hair samples, as well as with the Cu/Zn ratio in a cohort of 130 patients. Our findings describe a statistically significant inverse correlation between Cu content and the Cu/Zn ratio in hair samples and the extent of CAD. In contrast, no significant correlation was found between Zn content and the extent of CAD. Considering the scarcity of existing data on the subject, the analysis of hair samples could yield a novel insight into elemental deficiencies and their potential influence on CAD extent.https://www.mdpi.com/2079-7737/12/11/1407zinccoppercopper-to-zinc ratioatherosclerosiscoronary artery diseaseischemic heart disease |
| spellingShingle | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Ewa Czestkowska Joanna Beck Beata Jaczewska Elżbieta Zgnilec Andrzej Osiecki Mirosław Kwaśny Marek J. Dąbrowski Wacław Kochman Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score Biology zinc copper copper-to-zinc ratio atherosclerosis coronary artery disease ischemic heart disease |
| title | Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score |
| title_full | Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score |
| title_fullStr | Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score |
| title_full_unstemmed | Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score |
| title_short | Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score |
| title_sort | relationship between copper zinc and copper to zinc ratio in hair and severity of coronary artery disease according to the syntax score |
| topic | zinc copper copper-to-zinc ratio atherosclerosis coronary artery disease ischemic heart disease |
| url | https://www.mdpi.com/2079-7737/12/11/1407 |
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