Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease

Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease

Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson’s disease’s (PD). This study considers the potential utility of PD retinal biomarkers by investigating retinal changes in a well characterized PD model of α-SYN overexpressi...

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Bibliographic Details
Main Authors: Katie K. N. Tran, Vickie H. Y. Wong, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
A53T
alpha-synuclein
Parkinson’s disease
retina
electroretinography
optical coherence tomography
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1146979/full

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