Screening of coformers for quercetin cocrystals through mechanochemical methods
Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an intere...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2022-01-01
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| Series: | Eclética Química |
| Online Access: | http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1238 |
| _version_ | 1798016405859205120 |
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| author | Fayene Zeferino Ribeiro de Souza Amanda Cosmo de Almeida Patrícia Osorio Ferreira Richard Perosa Fernandes Flávio Junior Caires |
| author_facet | Fayene Zeferino Ribeiro de Souza Amanda Cosmo de Almeida Patrícia Osorio Ferreira Richard Perosa Fernandes Flávio Junior Caires |
| author_sort | Fayene Zeferino Ribeiro de Souza |
| collection | DOAJ |
| description | Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility—among other properties—of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different. |
| first_indexed | 2024-04-11T15:50:18Z |
| format | Article |
| id | doaj.art-7915945d8a104cb687d9523f312ee642 |
| institution | Directory Open Access Journal |
| issn | 0100-4670 1678-4618 |
| language | English |
| last_indexed | 2024-04-11T15:50:18Z |
| publishDate | 2022-01-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Eclética Química |
| spelling | doaj.art-7915945d8a104cb687d9523f312ee6422022-12-22T04:15:18ZengUniversidade Estadual PaulistaEclética Química0100-46701678-46182022-01-01471647510.26850/1678-4618eqj.v47.1.2022.p64-751122Screening of coformers for quercetin cocrystals through mechanochemical methodsFayene Zeferino Ribeiro de Souza0Amanda Cosmo de Almeida1Patrícia Osorio Ferreira2Richard Perosa Fernandes3Flávio Junior Caires4Federal Technological University of Paraná, Chemistry Department, Medianeira, Brazil.Federal Technological University of Paraná, Chemistry Department, Medianeira, Brazil.Federal Technological University of Paraná, Chemistry Department, Medianeira, Brazil.São Paulo State University, Institute of Chemistry, Araraquara, Brazil.Federal Technological University of Paraná, Chemistry Department, Medianeira, Brazil.Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility—among other properties—of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different.http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1238 |
| spellingShingle | Fayene Zeferino Ribeiro de Souza Amanda Cosmo de Almeida Patrícia Osorio Ferreira Richard Perosa Fernandes Flávio Junior Caires Screening of coformers for quercetin cocrystals through mechanochemical methods Eclética Química |
| title | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| title_full | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| title_fullStr | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| title_full_unstemmed | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| title_short | Screening of coformers for quercetin cocrystals through mechanochemical methods |
| title_sort | screening of coformers for quercetin cocrystals through mechanochemical methods |
| url | http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1238 |
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