Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters
The biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Saudi Pharmaceutical Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016417301986 |
| _version_ | 1818266110974230528 |
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| author | Nouf M. Al-Enazi Amani S. Awaad Saleh I. Alqasoumi Metab F. Alwethairi |
| author_facet | Nouf M. Al-Enazi Amani S. Awaad Saleh I. Alqasoumi Metab F. Alwethairi |
| author_sort | Nouf M. Al-Enazi |
| collection | DOAJ |
| description | The biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of Galaxaura rugosa showed antibacterial activity against Klebsiella pneumoniae (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, 0.49 mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25 mm, 1.25, 0.312 and 0.156 mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27 mm, 1.25, 0.312 and 0.156 mg/ml) against Aspergillus fumigatus, A. niger and Candida trobicalis, respectively. A good antioxidant activity (80.96%, IC50 = 27.8 µg/ml) was provided by Galaxaura rugosa. The anticancer activity results revealed that the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana possessed antitumor activity (IC50 = 15 ± 1.7 and 21.2 ± 1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC50 = 24.6 ± 0.7). Although, the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC50 = 10.2 ± 0.6 and 12.2 ± 0.6, respectively) preferable than vinblastine sulfate (IC50 = 59.7 ± 2.1 and 30.3 ± 1.4, respectively). Keywords: Phytochemical screening, Antitumor, Antioxidant, Antimicrobial, Extraction |
| first_indexed | 2024-12-12T20:01:30Z |
| format | Article |
| id | doaj.art-791660d6b95e4cbaa898b1db8f704c3e |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-12-12T20:01:30Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-791660d6b95e4cbaa898b1db8f704c3e2022-12-22T00:13:45ZengElsevierSaudi Pharmaceutical Journal1319-01642018-01-012612532Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana buttersNouf M. Al-Enazi0Amani S. Awaad1Saleh I. Alqasoumi2Metab F. Alwethairi3Biology Department, College of Science and Humanity Studies, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi ArabiaPharmacognosy Department, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia; Corresponding author at: P.O. Box 173, Riyadh 11942, Saudi Arabia.Pharmacognosy Department, College of Pharmacy, King Saud University, Saudi ArabiaClinical Pharmacist, King Abdulaziz Medicinal City, Saudi ArabiaThe biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of Galaxaura rugosa showed antibacterial activity against Klebsiella pneumoniae (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, 0.49 mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25 mm, 1.25, 0.312 and 0.156 mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27 mm, 1.25, 0.312 and 0.156 mg/ml) against Aspergillus fumigatus, A. niger and Candida trobicalis, respectively. A good antioxidant activity (80.96%, IC50 = 27.8 µg/ml) was provided by Galaxaura rugosa. The anticancer activity results revealed that the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana possessed antitumor activity (IC50 = 15 ± 1.7 and 21.2 ± 1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC50 = 24.6 ± 0.7). Although, the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC50 = 10.2 ± 0.6 and 12.2 ± 0.6, respectively) preferable than vinblastine sulfate (IC50 = 59.7 ± 2.1 and 30.3 ± 1.4, respectively). Keywords: Phytochemical screening, Antitumor, Antioxidant, Antimicrobial, Extractionhttp://www.sciencedirect.com/science/article/pii/S1319016417301986 |
| spellingShingle | Nouf M. Al-Enazi Amani S. Awaad Saleh I. Alqasoumi Metab F. Alwethairi Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters Saudi Pharmaceutical Journal |
| title | Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters |
| title_full | Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters |
| title_fullStr | Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters |
| title_full_unstemmed | Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters |
| title_short | Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters |
| title_sort | biological activities of the red algae galaxaura rugosa and liagora hawaiiana butters |
| url | http://www.sciencedirect.com/science/article/pii/S1319016417301986 |
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