PIMT regulates hepatic gluconeogenesis in mice

PIMT regulates hepatic gluconeogenesis in mice

Summary: The physiological and metabolic functions of PIMT/TGS1, a third-generation transcriptional apparatus protein, in glucose homeostasis sustenance are unclear. Here, we observed that the expression of PIMT was upregulated in the livers of short-term fasted and obese mice. Lentiviruses expressi...

Full description

Bibliographic Details
Main Authors:	Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V.L. Parsa, Parimal Misra
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Series:	iScience
Subjects:	Hepatology Human metabolism Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223001979

Similar Items

PIMT Controls Insulin Synthesis and Secretion through PDX1
by: Rahul Sharma, et al.
Published: (2023-04-01)

Multitissue 2H/13C flux analysis reveals reciprocal upregulation of renal gluconeogenesis in hepatic PEPCK-C–knockout mice
by: Mohsin Rahim, et al.
Published: (2021-06-01)

Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators
by: Kostas C. Nikolaou, et al.
Published: (2023-11-01)

Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2
by: Naiyuan Cheng, et al.
Published: (2022-07-01)

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
by: Neha Bhat, et al.
Published: (2022-02-01)

Hepatology and Gastroenterology /
by: Drake, Verdie, author 648337, et al.
Published: (2012)

The circulating proteomic signature of alcohol-associated liver disease
by: Jay Luther, et al.
Published: (2022-07-01)

Concerns about the inverse relationship between baseline HBV DNA and on-treatment hepatocellular carcinoma risk. Reply.
by: Won-Mook Choi, et al.
Published: (2022-08-01)

Concerns about the inverse relationship between baseline HBV DNA and on-treatment hepatocellular carcinoma risk
by: Shi Liu, et al.
Published: (2022-08-01)

The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease
by: Zhihong Yang, et al.
Published: (2021-08-01)

Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation
by: Emilie Crouchet, et al.
Published: (2022-07-01)

The development of novel therapeutic vaccines for chronic hepatitis B infection
by: Cargill, TN
Published: (2021)

FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
by: Aki T. Chaffin, et al.
Published: (2022-10-01)

Blood-derived lysophospholipid sustains hepatic phospholipids and fat storage necessary for hepatoprotection in overnutrition
by: Cheen Fei Chin, et al.
Published: (2023-09-01)

Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
by: Stephania Guzman, et al.
Published: (2022-05-01)

Asparagine protects pericentral hepatocytes during acute liver injury
by: Yu Sun, et al.
Published: (2023-04-01)

Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models
by: Toshiya Matsukawa, et al.
Published: (2023-09-01)

CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury
by: Yuzo Koda, et al.
Published: (2022-09-01)

Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response
by: Takeshi Chida, et al.
Published: (2023-05-01)

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84
by: Ryuji Ohue-Kitano, et al.
Published: (2023-01-01)

Increasing on-treatment hepatocellular carcinoma risk with decreasing baseline viral load in HBeAg-positive chronic hepatitis B
by: Won-Mook Choi, et al.
Published: (2022-05-01)

Endo-Hepatology: The Buzz Goes Much beyond Liver Biopsy—A Narrative Review
by: Rajesh Puri, et al.
Published: (2023-12-01)

Comparison of anal dilatation versus no dilatation with a standardized dilator in reducing pain after hemorrhoidectomy: a randomized control trial
by: Sofii, Imam, et al.
Published: (2022)

National Consensus on Portal Hypertension Management in Indonesia
by: Kurniawan, Juferdy, et al.
Published: (2022)

Predictor of Liver Biochemistry Improvement in Patients with Cytomegalovirus Cholestasis after Ganciclovir Treatment
by: Puspita, Gina, et al.
Published: (2022)

Genetics in liver disease /
by: Blum, H. E.
Published: (2007)

Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation
by: Jingyuan Sun, et al.
Published: (2023-07-01)

Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis
by: Nidhi Jalan-Sakrikar, et al.
Published: (2023-10-01)

Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease
by: Susheel K. Gunasekar, et al.
Published: (2023-03-01)

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
by: Raanan Greenman, et al.
Published: (2023-06-01)

Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice
by: Jennifer K. Truong, et al.
Published: (2023-03-01)

Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease
by: Nobuharu Tamaki, et al.
Published: (2022-11-01)

Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver
by: Xiaorong Fu, et al.
Published: (2023-05-01)

In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis
by: Wei Liu, et al.
Published: (2023-04-01)

Hepatocyte SREBP signaling mediates clock communication within the liver
by: Dongyin Guan, et al.
Published: (2023-04-01)

Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
by: Dechun Feng, et al.
Published: (2023-08-01)

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
by: Weiwei Dai, et al.
Published: (2022-12-01)

Genome editing without nucleases confers proliferative advantage to edited hepatocytes and corrects Wilson disease
by: Agnese Padula, et al.
Published: (2023-11-01)

Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic steatohepatitis via Notch/osteopontin signaling
by: Yue Li, et al.
Published: (2022-12-01)

Targeting BCL-XL in fibrolamellar hepatocellular carcinoma
by: Bassem Shebl, et al.
Published: (2022-09-01)