Cellular Mechanisms of FGF-Stimulated Tissue Repair
Growth factors belonging to the FGF family play important roles in tissue and organ repair after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular behavior important for reparative processes. In particular, I focus on the FGF-dependent regulation of cell proliferati...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/7/1830 |
| _version_ | 1827687731708297216 |
|---|---|
| author | Igor Prudovsky |
| author_facet | Igor Prudovsky |
| author_sort | Igor Prudovsky |
| collection | DOAJ |
| description | Growth factors belonging to the FGF family play important roles in tissue and organ repair after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular behavior important for reparative processes. In particular, I focus on the FGF-dependent regulation of cell proliferation, cell stemness, de-differentiation, inflammation, angiogenesis, cell senescence, cell death, and the production of proteases. In addition, I review the available literature on the enhancement of FGF expression and secretion in damaged tissues resulting in the increased FGF supply required for tissue repair. |
| first_indexed | 2024-03-10T09:43:11Z |
| format | Article |
| id | doaj.art-79172a97fafe43faab05df606bc6b50b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:11Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-79172a97fafe43faab05df606bc6b50b2023-11-22T03:30:51ZengMDPI AGCells2073-44092021-07-01107183010.3390/cells10071830Cellular Mechanisms of FGF-Stimulated Tissue RepairIgor Prudovsky0Maine Medical Center Research Institute, 81 Research Dr., Scarborough, ME 04074, USAGrowth factors belonging to the FGF family play important roles in tissue and organ repair after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular behavior important for reparative processes. In particular, I focus on the FGF-dependent regulation of cell proliferation, cell stemness, de-differentiation, inflammation, angiogenesis, cell senescence, cell death, and the production of proteases. In addition, I review the available literature on the enhancement of FGF expression and secretion in damaged tissues resulting in the increased FGF supply required for tissue repair.https://www.mdpi.com/2073-4409/10/7/1830FGFrepairregenerationproliferationstemnessde-differentiation |
| spellingShingle | Igor Prudovsky Cellular Mechanisms of FGF-Stimulated Tissue Repair Cells FGF repair regeneration proliferation stemness de-differentiation |
| title | Cellular Mechanisms of FGF-Stimulated Tissue Repair |
| title_full | Cellular Mechanisms of FGF-Stimulated Tissue Repair |
| title_fullStr | Cellular Mechanisms of FGF-Stimulated Tissue Repair |
| title_full_unstemmed | Cellular Mechanisms of FGF-Stimulated Tissue Repair |
| title_short | Cellular Mechanisms of FGF-Stimulated Tissue Repair |
| title_sort | cellular mechanisms of fgf stimulated tissue repair |
| topic | FGF repair regeneration proliferation stemness de-differentiation |
| url | https://www.mdpi.com/2073-4409/10/7/1830 |
| work_keys_str_mv | AT igorprudovsky cellularmechanismsoffgfstimulatedtissuerepair |