Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells

Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells

Resistance to chemotherapeutic agents is a major obstacle in cancer treatment. A recently proposed strategy is to target the collateral sensitivity of multidrug resistant (MDR) cancer. Paradoxically, the toxicity of certain metal chelating agents is increased, rather than decreased, by the function...

Full description

Bibliographic Details
Main Authors: Veronika F.S. Pape, Anikó Gaál, István Szatmári, Nóra Kucsma, Norbert Szoboszlai, Christina Streli, Ferenc Fülöp, Éva A. Enyedy, Gergely Szakács
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
cancer
multidrug resistance
reactive oxygen species
metal-based drugs
collateral sensitivity
Online Access:https://www.mdpi.com/2072-6694/13/1/154

Internet

https://www.mdpi.com/2072-6694/13/1/154

Similar Items