Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty
The administration of zoledronic acid (ZA) to patients who received cementless total hip arthroplasty (THA) has been reported to reduce bone turnover markers (BTMs) and increase bone mineral density (BMD). The effects of two-dose ZA versus placebo on cementless THA patients were analyzed in this fiv...
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MDPI AG
2022-03-01
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| Online Access: | https://www.mdpi.com/1424-8247/15/4/420 |
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| author | Allen Herng Shouh Hsu Chun-Hsien Yen Feng-Chih Kuo Cheng-Ta Wu Tsan-Wen Huang Juei-Tang Cheng Mel S. Lee |
| author_facet | Allen Herng Shouh Hsu Chun-Hsien Yen Feng-Chih Kuo Cheng-Ta Wu Tsan-Wen Huang Juei-Tang Cheng Mel S. Lee |
| author_sort | Allen Herng Shouh Hsu |
| collection | DOAJ |
| description | The administration of zoledronic acid (ZA) to patients who received cementless total hip arthroplasty (THA) has been reported to reduce bone turnover markers (BTMs) and increase bone mineral density (BMD). The effects of two-dose ZA versus placebo on cementless THA patients were analyzed in this five-year extension study. Alkaline phosphatase (ALP), osteocalcin (OC), procollagen 1 intact N-terminal propeptide (P1NP), serum calcium, renal function, radiological findings, and functional outcomes were compared in 49 patients, and the periprosthetic BMD of seven Gruen zones were compared in 19 patients. All the patients had normal renal function and calcium levels at their final follow-up. The mean ALP level in the ZA group was significantly lower at the fifth year, mean OC levels were significantly lower at the second and fifth year, and mean P1NP levels were significantly lower from 6 weeks to 5 years as compared with the control group. Fifth-year BMD levels were not found to be different between the ZA and control groups. The BMD Change Ratios in the ZA group were significantly increased in Gruen zone 6 at 1, 2, and 5 years. Our study results suggest that short-term ZA treatment with a subsequent 4-year drug holiday may inhibit serum BTMs and provide periprosthetic bone preservation at five years without adverse events. |
| first_indexed | 2024-03-09T10:31:11Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T10:31:11Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-791c86f3f1a44b948c80d1f88403be562023-12-01T21:18:03ZengMDPI AGPharmaceuticals1424-82472022-03-0115442010.3390/ph15040420Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip ArthroplastyAllen Herng Shouh Hsu0Chun-Hsien Yen1Feng-Chih Kuo2Cheng-Ta Wu3Tsan-Wen Huang4Juei-Tang Cheng5Mel S. Lee6Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung City 833, TaiwanMinistry of Health and Welfare Cishan Hospital, Kaohsiung City 842, TaiwanDepartment of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung City 833, TaiwanDepartment of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung City 833, TaiwanDepartment of Orthopedic Surgery, Chia-Yi Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Chiayi City 621, TaiwanDepartment of Medical Research, Chi-Mei Hospital, Tainan City 710, TaiwanDepartment of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung City 833, TaiwanThe administration of zoledronic acid (ZA) to patients who received cementless total hip arthroplasty (THA) has been reported to reduce bone turnover markers (BTMs) and increase bone mineral density (BMD). The effects of two-dose ZA versus placebo on cementless THA patients were analyzed in this five-year extension study. Alkaline phosphatase (ALP), osteocalcin (OC), procollagen 1 intact N-terminal propeptide (P1NP), serum calcium, renal function, radiological findings, and functional outcomes were compared in 49 patients, and the periprosthetic BMD of seven Gruen zones were compared in 19 patients. All the patients had normal renal function and calcium levels at their final follow-up. The mean ALP level in the ZA group was significantly lower at the fifth year, mean OC levels were significantly lower at the second and fifth year, and mean P1NP levels were significantly lower from 6 weeks to 5 years as compared with the control group. Fifth-year BMD levels were not found to be different between the ZA and control groups. The BMD Change Ratios in the ZA group were significantly increased in Gruen zone 6 at 1, 2, and 5 years. Our study results suggest that short-term ZA treatment with a subsequent 4-year drug holiday may inhibit serum BTMs and provide periprosthetic bone preservation at five years without adverse events.https://www.mdpi.com/1424-8247/15/4/420bisphosphonatezoledronic acidtotal hip arthroplastybone mineral densitybone turnover marker |
| spellingShingle | Allen Herng Shouh Hsu Chun-Hsien Yen Feng-Chih Kuo Cheng-Ta Wu Tsan-Wen Huang Juei-Tang Cheng Mel S. Lee Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty Pharmaceuticals bisphosphonate zoledronic acid total hip arthroplasty bone mineral density bone turnover marker |
| title | Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty |
| title_full | Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty |
| title_fullStr | Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty |
| title_full_unstemmed | Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty |
| title_short | Zoledronic Acid Ameliorates the Bone Turnover Activity and Periprosthetic Bone Preservation in Cementless Total Hip Arthroplasty |
| title_sort | zoledronic acid ameliorates the bone turnover activity and periprosthetic bone preservation in cementless total hip arthroplasty |
| topic | bisphosphonate zoledronic acid total hip arthroplasty bone mineral density bone turnover marker |
| url | https://www.mdpi.com/1424-8247/15/4/420 |
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