PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
In spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have underta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/37 |
| _version_ | 1797198166146154496 |
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| author | A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva |
| author_facet | A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva |
| author_sort | A. V. Shevchenko |
| collection | DOAJ |
| description | In spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have undertaken an analysis of genotypic frequencies in promoter regions of IL-4, IL-6 and IL-10 genes for a group of relatively healthy women and patients with breast cancer. Some specific features of allelic distribution have been found in groups of healthy women, among cohorts with hereditary predisposition, including the patients with breast cancer who had clustering of the disease in families (i.e., mother, grandmother, or sister been affected). |
| first_indexed | 2024-03-08T05:51:41Z |
| format | Article |
| id | doaj.art-791e00c302b14dcd872f74401f884c07 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:32Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-791e00c302b14dcd872f74401f884c072024-04-22T13:07:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111212810.15789/1563-0625-2009-1-21-2836PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCERA. V. Shevchenko0O. V. Golovanova1M. Ju. Kolomejtchuk2V. I. Konenkov3E. Ju. Garbukov4M. N. Stakheeva5ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскГУ НИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскГУ НИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскГУ НИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскГУ НИИ онкологии Томского научного центра СО РАМНГУ НИИ онкологии Томского научного центра СО РАМНIn spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have undertaken an analysis of genotypic frequencies in promoter regions of IL-4, IL-6 and IL-10 genes for a group of relatively healthy women and patients with breast cancer. Some specific features of allelic distribution have been found in groups of healthy women, among cohorts with hereditary predisposition, including the patients with breast cancer who had clustering of the disease in families (i.e., mother, grandmother, or sister been affected).https://www.mimmun.ru/mimmun/article/view/37breast cancerpolymorphismil-4il-6il-10 |
| spellingShingle | A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER Медицинская иммунология breast cancer polymorphism il-4 il-6 il-10 |
| title | PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER |
| title_full | PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER |
| title_fullStr | PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER |
| title_full_unstemmed | PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER |
| title_short | PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER |
| title_sort | promotor polymorphism of il 4 il 6 and il 10 genes among patients with breast cancer |
| topic | breast cancer polymorphism il-4 il-6 il-10 |
| url | https://www.mimmun.ru/mimmun/article/view/37 |
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