Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women
Abstract Background Studies on the association of gestational diabetes mellitus (GDM) with osteoporosis, and bone mineral density (BMD) have been inconsistent. The aim of this study was to investigate the association of a history of GDM with osteoporosis, BMD, and trabecular bone score (TBS) in post...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-023-01194-8 |
| _version_ | 1797647266270412800 |
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| author | Boqi Lu Liping Zhang |
| author_facet | Boqi Lu Liping Zhang |
| author_sort | Boqi Lu |
| collection | DOAJ |
| description | Abstract Background Studies on the association of gestational diabetes mellitus (GDM) with osteoporosis, and bone mineral density (BMD) have been inconsistent. The aim of this study was to investigate the association of a history of GDM with osteoporosis, BMD, and trabecular bone score (TBS) in postmenopausal women. Methods Postmenopausal women from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2010, between 2013 and 2014, and between 2017 and 2018 were retrospectively included in this cross-sectional study. The logistic regression model was used to explore the relationship between GDM and osteoporosis, and a weighted linear regression model was applied to investigate the association between GDM and total femoral BMD, femoral neck BMD, and total TBS. Subgroup analysis of the association between GDM and osteoporosis was performed according to age, body mass index (BMI), and DM (yes or no). Results Of the 6732 women included, 253 women (3.76%) had GDM. No significant differences in total femoral BMD, femoral neck BMD, and total TBS were observed between postmenopausal women with and without a history of GDM. However, a history of GDM was associated with a higher risk of osteoporosis in postmenopausal women [odds ratio (OR): 11.18, 95% confidence intervals (CI): 3.64 to 34.27, P < 0.001]. There was no significant difference between a history of GDM and osteoporosis in postmenopausal women whom BMI is normal and overweight women. However, there was an association between a history of GDM and osteoporosis in postmenopausal obese women (OR: 26.57, 95% CI 10.23 to 68.98, P < 0.001). Conclusion A history of GDM was associated with a higher risk of osteoporosis in postmenopausal women, particularly in postmenopausal obese women. |
| first_indexed | 2024-03-11T15:13:50Z |
| format | Article |
| id | doaj.art-791e8731528a4d14a2a844ddcc2f123f |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-03-11T15:13:50Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-791e8731528a4d14a2a844ddcc2f123f2023-10-29T12:31:04ZengBMCDiabetology & Metabolic Syndrome1758-59962023-10-011511810.1186/s13098-023-01194-8Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal womenBoqi Lu0Liping Zhang1Department of Obstetrics, Haidian District Maternal and Child Health Care HospitalDepartment of Obstetrics, Huai’an Maternal and Child Health Care CenterAbstract Background Studies on the association of gestational diabetes mellitus (GDM) with osteoporosis, and bone mineral density (BMD) have been inconsistent. The aim of this study was to investigate the association of a history of GDM with osteoporosis, BMD, and trabecular bone score (TBS) in postmenopausal women. Methods Postmenopausal women from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2010, between 2013 and 2014, and between 2017 and 2018 were retrospectively included in this cross-sectional study. The logistic regression model was used to explore the relationship between GDM and osteoporosis, and a weighted linear regression model was applied to investigate the association between GDM and total femoral BMD, femoral neck BMD, and total TBS. Subgroup analysis of the association between GDM and osteoporosis was performed according to age, body mass index (BMI), and DM (yes or no). Results Of the 6732 women included, 253 women (3.76%) had GDM. No significant differences in total femoral BMD, femoral neck BMD, and total TBS were observed between postmenopausal women with and without a history of GDM. However, a history of GDM was associated with a higher risk of osteoporosis in postmenopausal women [odds ratio (OR): 11.18, 95% confidence intervals (CI): 3.64 to 34.27, P < 0.001]. There was no significant difference between a history of GDM and osteoporosis in postmenopausal women whom BMI is normal and overweight women. However, there was an association between a history of GDM and osteoporosis in postmenopausal obese women (OR: 26.57, 95% CI 10.23 to 68.98, P < 0.001). Conclusion A history of GDM was associated with a higher risk of osteoporosis in postmenopausal women, particularly in postmenopausal obese women.https://doi.org/10.1186/s13098-023-01194-8Gestational diabetes mellitusOsteoporosisBone mineral densityTrabecular bone scorePostmenopausal women |
| spellingShingle | Boqi Lu Liping Zhang Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women Diabetology & Metabolic Syndrome Gestational diabetes mellitus Osteoporosis Bone mineral density Trabecular bone score Postmenopausal women |
| title | Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women |
| title_full | Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women |
| title_fullStr | Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women |
| title_full_unstemmed | Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women |
| title_short | Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women |
| title_sort | association of a history of gestational diabetes mellitus with osteoporosis bone mineral density and trabecular bone score in postmenopausal women |
| topic | Gestational diabetes mellitus Osteoporosis Bone mineral density Trabecular bone score Postmenopausal women |
| url | https://doi.org/10.1186/s13098-023-01194-8 |
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