Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells

Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells

Evaluation of sepsis-induced immunoparalysis has highlighted how decreased lymphocyte number/function contribute to worsened infection/cancer. Yet, an interesting contrast exists with autoimmune disease development, wherein diminishing pathogenic effectors may benefit the post-septic host. Within th...

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Bibliographic Details
Main Authors: Isaac J Jensen, Samantha N Jensen, Frances V Sjaastad, Katherine N Gibson-Corley, Thamothrampillai Dileepan, Thomas S Griffith, Ashutosh K Mangalam, Vladimir P Badovinac
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
sepsis
EAE
CD4 T cells
immunoparalysis
adoptive transfer
Online Access:https://elifesciences.org/articles/55800

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