Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease
Abstract Introduction Determining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings. Methods Participants aged 50 to 75 years attending...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12151 |
| _version_ | 1828085306218250240 |
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| author | Tobias Möllers Hannah Stocker Laura Perna Andreas Nabers Dan Rujescu Annette M. Hartmann Bernd Holleczek Ben Schöttker Klaus Gerwert Hermann Brenner |
| author_facet | Tobias Möllers Hannah Stocker Laura Perna Andreas Nabers Dan Rujescu Annette M. Hartmann Bernd Holleczek Ben Schöttker Klaus Gerwert Hermann Brenner |
| author_sort | Tobias Möllers |
| collection | DOAJ |
| description | Abstract Introduction Determining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings. Methods Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community‐based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available Aβ misfolding measurements and clinical AD information at 17‐year follow‐up were included (n = 444). Results Age did not show any association with Aβ misfolding in plasma; however, a strong association of both age and Aβ misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with Aβ misfolding. Discussion Structural measurement of Aβ misfolding in blood plasma is an age‐independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood. |
| first_indexed | 2024-04-11T04:36:56Z |
| format | Article |
| id | doaj.art-791eeea64a2941e89e6731739fc14687 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:36:56Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-791eeea64a2941e89e6731739fc146872022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12151Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's diseaseTobias Möllers0Hannah Stocker1Laura Perna2Andreas Nabers3Dan Rujescu4Annette M. Hartmann5Bernd Holleczek6Ben Schöttker7Klaus Gerwert8Hermann Brenner9Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg GermanyDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg GermanyDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg GermanyDepartment of Biophysics Ruhr‐University Bochum Bochum GermanyPsychotherapy and Psychosomatics University Clinic and Outpatient Clinic for Psychiatry Martin‐Luther‐University Halle‐Wittenberg Halle/Saale GermanyPsychotherapy and Psychosomatics University Clinic and Outpatient Clinic for Psychiatry Martin‐Luther‐University Halle‐Wittenberg Halle/Saale GermanySaarland Cancer Registry Saarbrücken GermanyDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg GermanyDepartment of Biophysics Ruhr‐University Bochum Bochum GermanyDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg GermanyAbstract Introduction Determining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings. Methods Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community‐based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available Aβ misfolding measurements and clinical AD information at 17‐year follow‐up were included (n = 444). Results Age did not show any association with Aβ misfolding in plasma; however, a strong association of both age and Aβ misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with Aβ misfolding. Discussion Structural measurement of Aβ misfolding in blood plasma is an age‐independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood.https://doi.org/10.1002/dad2.12151ageAlzheimer's diseaseamyloid beta misfoldingcohort studyrisk factors |
| spellingShingle | Tobias Möllers Hannah Stocker Laura Perna Andreas Nabers Dan Rujescu Annette M. Hartmann Bernd Holleczek Ben Schöttker Klaus Gerwert Hermann Brenner Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring age Alzheimer's disease amyloid beta misfolding cohort study risk factors |
| title | Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease |
| title_full | Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease |
| title_fullStr | Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease |
| title_full_unstemmed | Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease |
| title_short | Aβ misfolding in blood plasma measured by immuno‐infrared‐sensor as an age‐independent risk marker of Alzheimer's disease |
| title_sort | aβ misfolding in blood plasma measured by immuno infrared sensor as an age independent risk marker of alzheimer s disease |
| topic | age Alzheimer's disease amyloid beta misfolding cohort study risk factors |
| url | https://doi.org/10.1002/dad2.12151 |
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