Innate Immune Responses in Leprosy
Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determ...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00518/full |
| _version_ | 1811242285423132672 |
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| author | Roberta Olmo Pinheiro Veronica Schmitz Bruno Jorge de Andrade Silva André Alves Dias Beatriz Junqueira de Souza Mayara Garcia de Mattos Barbosa Danuza de Almeida Esquenazi Maria Cristina Vidal Pessolani Euzenir Nunes Sarno |
| author_facet | Roberta Olmo Pinheiro Veronica Schmitz Bruno Jorge de Andrade Silva André Alves Dias Beatriz Junqueira de Souza Mayara Garcia de Mattos Barbosa Danuza de Almeida Esquenazi Maria Cristina Vidal Pessolani Euzenir Nunes Sarno |
| author_sort | Roberta Olmo Pinheiro |
| collection | DOAJ |
| description | Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management. |
| first_indexed | 2024-04-12T13:49:26Z |
| format | Article |
| id | doaj.art-791f47e2758e4eb89f076948230104c2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T13:49:26Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-791f47e2758e4eb89f076948230104c22022-12-22T03:30:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-03-01910.3389/fimmu.2018.00518314064Innate Immune Responses in LeprosyRoberta Olmo Pinheiro0Veronica Schmitz1Bruno Jorge de Andrade Silva2André Alves Dias3Beatriz Junqueira de Souza4Mayara Garcia de Mattos Barbosa5Danuza de Almeida Esquenazi6Maria Cristina Vidal Pessolani7Euzenir Nunes Sarno8Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00518/fullleprosyinnate immune responsesskinMycobacterium lepraeautophagytoll-like receptors |
| spellingShingle | Roberta Olmo Pinheiro Veronica Schmitz Bruno Jorge de Andrade Silva André Alves Dias Beatriz Junqueira de Souza Mayara Garcia de Mattos Barbosa Danuza de Almeida Esquenazi Maria Cristina Vidal Pessolani Euzenir Nunes Sarno Innate Immune Responses in Leprosy Frontiers in Immunology leprosy innate immune responses skin Mycobacterium leprae autophagy toll-like receptors |
| title | Innate Immune Responses in Leprosy |
| title_full | Innate Immune Responses in Leprosy |
| title_fullStr | Innate Immune Responses in Leprosy |
| title_full_unstemmed | Innate Immune Responses in Leprosy |
| title_short | Innate Immune Responses in Leprosy |
| title_sort | innate immune responses in leprosy |
| topic | leprosy innate immune responses skin Mycobacterium leprae autophagy toll-like receptors |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00518/full |
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